Griseofulvin

Griseofulvin is an antifungal medication used to treat a number of types of dermatophytoses. This includes fungal infections of the nails and skin when antifungal creams have not worked. It is taken by mouth.

Griseofulvin

Griseofulvin; (+)-Griseofulvin; 126-07-8; Amudane; Fulvicin

Dermonorm, Fluvin, Fungal, Fungivin, Geovin, Griderm, Gris-OD, Grisactin Forte, Grisomed, Grisonorm, Grisoral, Grisovin-FP, Grisovin-FP, Idifulvin, Microfulvin, Microfulvin-250, Myconorm Tab, Nufulvin, Walavin

(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[1-benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione

NA

It was the first available oral agent for the treatment of dermatophytoses. Griseofulvin is a mycotoxic metabolic product of Penicillium spp.  Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions. 

PO- 0.5-1 g/day. Hair and skin infections: 2-8 week. Fingernail infections: 6 months. Toenail infections: 12 months or more. 

For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.

Oral thrush; GI distress, taste perversion; dizziness, confusion, headache, depression, insomnia, fatigue; peripheral neuritis, photosensitivity; skin rashes, urticaria, erythema multiforme; leucopenia, proteinuria.

• Antagonises oral anticoagulants and oral contraceptives. Decreased GI absorption with phenobarbital. Reduced plasma concentrations with enzyme inducers e.g. phenylbutazone and hypnotics.
• Enhances effects of alcohol and causes disulfiram-like reaction.
• High-fat meal enhances absorption

Severe liver disease; porphyria; monilial infection; SLE; pregnancy

Store at 15-30°C

Molecular weight

352.766

Molecular formula

C17H17ClO6

CAS number

126-07-8

Precautions

Lactation; may impair ability to drive or operate machinery; avoid exposure to intense sunlight or artificial light. Regular monitoring of the renal, hepatic and blood tests should be done.