Heparin

Heparin, also known as unfractionated heparin, is medication which is used as an anticoagulant. Specifically it is used to treat and prevent deep vein thrombosis, pulmonary embolism, and arterial thromboembolism.

Heparin

Innohep; Reviparin sodium; Tinzaparin sodium; Heparin, sodium salt; Logiparin; Panheprin

Beparin Gel, Beparine, Beparine CRM, Beparine-LF, Beprin, Bioclot, Blockasol, Caprin, Cathflush, Celparin, Daltehep, Declot, Fobrin, Geohep, Hep, Heparen, Heparin, Hepawin Tab, Hepflo, Hepgel, Heplock, Ignava, Inhep, Keparin, Line Flush, Logiparin, No-Clot, Nuparin, Swithromb, Thrombogel, Thromboparin, Thrombophob, Thrombophob Gel, Thrombophob OINT, Thrombotas, Troparin, Unihep, Unithromb, V-parin

(4S,6R)-6-[(2R,4R)-4,6-dihydroxy-5-(sulfonatoamino)-2-(sulfonatooxymethyl)oxan-3-yl]oxy-3,4-dihydroxy-5-sulfonatooxyoxane-2-carboxylate

Absorbed from systemic circulation (IV, SC) and excreted via urine.

NA

Adult: IV- Loading dose: 5,000 u, then 1,000-2,000 u/hr.

This medication is an anticoagulant, prescribed for deep venous thrombosis, arterial embolism and pulmonary embolism. It is also used for prevention of blood clot in heart surgery. It decreases the clotting ability of the blood.

Slight fever, headache, chills, nausea, vomiting, constipation, epistaxis, bruising, slight haematuria, skin necrosis (SC inj), osteoporosis, alopecia. Hypersensitivity reactions include urticaria, conjunctivitis, rhinitis, asthma, angioedema and anaphylactic shock. Priapism. Potentially Fatal: Heparin-induced thrombocytopenia with or without thrombosis; bleeding.

·         Inhibited by zinc.

·         Antiplatelet drugs e.g. aspirin and dipyridamole may precipitate bleeding.NSAIDs may increase risk of haemorrhage.

·         Effect increased by high doses of penicillin, dextrans and cephalosporins, asparaginase, phenylbutazone, streptokinase and some contrast media.

• Patients predisposed to active bleeding including thrombocytopenia, peptic ulcer disease, cerebrovascular disorders, haemorrhagic blood disorders, bacterial endocarditis, severe hypertension, oesophageal varices.
• Severe renal and hepatic impairment.
• Severe traumatic bleed, subarachnoid or cerebral haemorrhage, severe haemostatic defect, hepatic, renal, splenic or arterial injury, abdominal or thoracic bleeding into closed space, arterial thrombosis with heparin-associated thrombocytopenia.
• IM admin.

Store at 15-30°C

Molecular weight

591.435 g/mol

Molecular formula

C12H17NO20S3-4

CAS number

9005-49-6

Precautions

Monitor platelet counts. Discontinue treatment if thrombocytopenia occurs. Hypersensitivity, elderly, pregnancy.