Human normal immunoglobulin

Human normal immunoglobulin is derived from donations of pooled human plasma. It contains immunoglobulin G antibodies (IgG), to various viruses and bacteria present in the general population such as measles, hepatitis A, mumps, rubella and varicella. It has a distribution of IgG subclasses that is very close to that of the normal human plasma. It is therefore, used to provide passive immunisation against such diseases.

Human normal immunoglobulin

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Anti-D Vaccine, Aunativ, Bharglob, Cytotect, Flebogamma, Gama-Glob, Gamafine, Gamaglobin, Gamma-IV, Gamunex, Genexglob, Globucel, Histaglobulin, Histoglob, Immunorel, IV-Globulin, Iviglob-EX, Matergam-P, Meglob, Norglobin, Octagam, Rhesonativ, Rhesumen, Rhoclone, Venimmun, Verglob, Vinobulin

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IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders. These indications includes idiopathic thrombocytopenic purpura, Kawasaki disease, hypogammaglobulinemia, B cell chronic lymphocytic leukemia, bone marrow transplant complications, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), multiple sclerosis, rheumatoid arthritis, myesthenia gravis, Wiskott–Aldrich syndrome and inflammatory skin diseases.

Dizziness, light-headedness, nausea, vomiting, allergic and cutaneous reactions. Local pain and tenderness at the site of inj. IV admin may lead to systemic effects such as headache, chills and fever.

May interfere with the immune response to live measles vaccine, live mumps vaccine, live rubella vaccine and live varicella vaccine, therefore these vaccines should be given at least 3 weeks before or 3 months after the admin of the immunoglobulins.

Patients with selective immunoglobulin A deficiency. Prior anaphylactic reactions to immunoglobulin, blood or other blood-derived preparations.

Store at 2-8°C. 

Molecular weight

142682.3 Da

Molecular formula

C6332H9826N1692O1980S42

CAS number

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Precautions

• Increased risk of acute renal failure in patients with DM, renal impairment, hypovolaemia, overweight, concomitant nephrotoxic medicinal products or >65 years.
• Monitor urine output and serum creatinine levels during treatment.
• Live vaccines should generally be given 3 wk before or 3 mth after admin of normal immunoglobulin.
• Concurrent use of loop diuretics during IV infusion of immunoglobulin should be avoided.
• Pregnancy and lactation.