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Human serum albumin

This is used as a diagnostic radiopharmaceutical for intravenous imaging in the iodinated form (I 131) isolated from expired blood plasma. More

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Description

This is used as a diagnostic radiopharmaceutical for intravenous imaging in the iodinated form (I 131) isolated from expired blood plasma.

Generic Name

Human serum albumin

Chemical names

NA

Brand names

Abraxane, Alba, Albucel, Albudac, Albudion, Albumed, Albumeon, Albumin 20%, Albumin 5%, Albumina Umana, Alburel, Albutein, Biseko, Buminate, Granocyte, Human Albumin, Human Albumin (Baxter), Human Albumin (Paviour), Humin, ORAL POLIOMYELITIS VACCINE, Pacliall, Plasbumin, Roferon-A, Verglob, Volumin, Zenalb, Zy-Albumin

IUPAC name

NA

Pharmacokinetics

NA

Actions

Serum albumin is a soluble, monomeric protein necessary for maintaining and regulating the colloidal osmotic pressure of blood. This will increase the circulating plasma volume, thereby reducing the blood viscosity and hemoconcentration. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.

Dosage/Dosage form

Intravenous

Therapeutic uses

For treatment of severe blood loss, hypervolemia, and hypoproteinemia.

Adverse effects/Side effects

Allergic reactions, nausea, anaphylactic shock, vomiting, increased salivation, fever and chills; vascular overload, haemodilution and pulmonary oedema.

Interaction

Albumin solution should not be mixed by protein hydrolysates or alcoholic solutions. Risk of atypical reactions to ACE inhibitors in patients undergoing therapeutic plasma exchange with albumin human replacement.

Contraindications

Cardiac failure, severe anaemia, history of hypersensitivity, parenteral nutrition.

Storage

Store below 30°C. Do not freeze.

Information

Molecular weight

66472.2 Da

Molecular formula

C2936H4624N786O889S41

CAS number

9048-46-8

Precautions

Hypertension or low cardiac reserve; additional fluids for dehydrated patients. Monitor for signs of cardiac overload in injured or postoperative patients. May carry risk of viral transmission. Volume admin and rate of infusion must always be individualised according to situation and response. Pregnancy, lactation.