Hyaluronidase

Hyaluronidases are a family of enzymes that catalyse the degradation of hyaluronic acid (HA). Karl Meyer classified these enzymes in 1971 into three distinct groups, a scheme based on the enzyme reaction products.

Hyaluronidase

2,4-bis(1,3-benzodioxol-5-yl)-4-oxobutanoic acid; CHEMBL2000337; 9001-54-1; 88755-39-9; Hyaluronidase from streptomyces hyaluro-lyticus, 0.1uvial

Facidase, Facidase INJ, Hylorase, Hynidase, Spreadase

NA

NA

Hyaluronidase hydrolyzes hyaluronic acid and increase diffusion of injected drugs, thus facilitating their absorption. Hyaluronidase is used for enhancing absorption and distribution of other injected drugs.

NA

For increase of absorption and distribution of other injected drugs and for rehydration.

Hypersensitivity and anaphylaxis. Urticaria, occasional severe allergy.

• Action potentiated by urokinase especially in the treatment of MI. May increase absorption and toxicity of local anaesthetics.
• NSAIDs, heparin and salicylates inhibits the efficacy and spreading action of hyaluronidase.

Hypersensitivity, malignancy. Direct application to the cornea, reduction of swelling of bites or stings. Inj into or around infected area. IV admin; unexplained premature labour.

Refrigerate at 2-8°C

Molecular weight

C2455H3775N617O704S21

Molecular formula

53870.9 Da

CAS number

NA

Precautions

Impaired renal function. Infants, elderly. Patients with infections. Pregnancy, lactation.