Hydro-chlorothiazide

Hydrochlorothiazide is a diuretic medication often used to treat high blood pressure and swelling due to fluid build up.

Hydro-chlorothiazide

Hydrochlorothiazide; 58-93-5; Hypothiazide; Dichlotride; Esidrex

Olmat-AMH, Olmetrack-H, Amlodac-H, Anzitel-H, Aquazide, Arbitel-H, Arkamin-H, Asomex-D, Asomex-D 5, Astel-H, Aten-H, Atenova-H, Atol-H, Benitec-H, Beta-Biduret, Betacard-H, Biduret, Biduret-L, Biotel-H, Bp-Loride, Bpzide, Candesar-H, Co-Diovan, Coaprovel, Corbis-H, Cortel-H, Cresar-H, Culmi-H, Culol-H, Cupine-H, Cutel-H, Cutel-RH, Eritel-H, Esidrex, Eslo-D, Etela-H, Hipres-D, Hybreed-H, Hydrazide, Hydride, Hytel-H, Hyzide, Irovel-H, Jemax-H, Klorzide, Lodoz, Lovetel-H, Macsart-H, Miotel-H, Misar-H

6-chloro-1,1-dioxo-3,4-dihydro-2H-1??,2,4-benzothiadiazine-7-sulfonamide

50-60% absorption.

Thiazides such as hydrochlorothiazide promote water loss from the body (diuretics). They inhibit Na⁺/Cl^- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. 

• Edema- The recommended dose is 25-100 mg once daily or in divided doses.
• HTN- The recommended dose is 12.5 to 50 mg once daily. 

For the treatment of high blood pressure and management of edema.

Volume depletion& electrolyte imbalance, dry mouth, thirst, lethargy, drowsiness, muscle pain, & cramps, hypotension, hypersensitivity reactions, thrombocytopenia, pancreatitis, jaundice, fatigue, impotence, hyperglycaemia, anorxia, gastric irritation, nausea, vomiting, constiption, diarrhoea, sialadenitis, dizziness, raised Ca concentration. Hypersensitivity reactions.

• Diuretic- induced hypokalaemia may increase the toxicity of digitalis glycosides and risk of arrhythmias when used with drugs that prolong QT inteval.
• May increase serum concentrations of lithium when used together.
•  Concurrent use with alcohol, barbiturates & opoids may enhance diuertic - enhanced orthostatic hypotension.
• Antihypertensive effect may be reduced by corticosteriods, NSAIDs or carbenoxolone. May enhance the nephrotoxicity of NSAIDs.
• Enhnaces neuromuscular blocking action of competitive muscle relaxants.
• Impaired control of diabetics by oral hypoglycaemic agents.

Severe hepatic & renal impairment, Addison's disease, preexisting hypercalcaemia, anuria, sulphonamide allaergy. Pregnancy & lactation.

Store it at controlled room temperature (20° to 25°C).

Molecular weight

297.739

Molecular formula

C7H8ClN3O4S2

CAS number

58-93-5

Precautions

• Existing electrolyte disturbances, hepatic cirrhosis, severe heart failure, oedema, elderly, renal impairment.
• Monitor for signs or fluid & electrolyte disturbance.
• DM, hepatic impairment, gout, hyperlipidaemia, hyperuricaemia, hypercalcae,ia, ECG; LVH (Extrasystoles). May axacerbate or activate SLE in susecptible patients.