Hydrocortisone

Hydrocortisone, sold under a number of brand names, is the name for the hormone cortisol when supplied as a medication.

Hydrocortisone

Hydrocortisone; Cortisol; 50-23-7; Acticort; Cetacort

Acucort, Alcort, Anacort, Arvisone, Biosone, Cardol, Cipcorlin, Ciplorin, Cort-H, Cort-S, Cortecyclin, Cortis-S, Cortygard, Ctcort, Cutisoft, Depiwhite, Drocort, Drucort, Efcorlin INJ, Efficort, Eldercoid, Fucidin-H, Gatle-H, Geocort, H-Cort, H.S, Hisone, Hobutide, Hy-Sone INJ, Hyacan, Hycort, Hycort CRM, Hycoson, Hydrocortisone Sod Succinate, Hydrocortisone Sodium Succinate, Hyss, Hyver, Intacorlin, Irays, Joycort-HS, Labocort, Lacticare-HC, Locoid Lipocrm, Lycor, Lycortin-S, M-Cort, M-Lite, Melalite Plus, Multicort, Multifungin-H

(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,?.0¹¹,¹?]heptadec-6-en-5-one

NA

NA

IV- The recommended dose is 20mg per day.

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

• Rapid IV Injection may cause CV collapse.
• Abrupt withdrawal leading to acute adrenal insufficiency.
• Sodium and fluid retention.
• Potassium and calcium depletion.
• Muscle wasting, weakness, osteoporosis.
• GI disturbances and bleeding.
• Increased appetite and delayed wound healing.
• Bruising, striae, hirsutism, acne, flushing.
• Raised intracranial pressure, headache, depression, psychosis, menstrual irregularities.
• Topical use: Dermal atrophy, folliculitis, local irritation, hypertrichosis.
• Hyperglycaemia, glycosuria, DM, obesity, moon-face, buffalo hump.
• Topical application to the eye: Can produce corneal ulcers, raised IOP and reduced visual function.
• Suppression of pituitary-adrenocortical system.
• Intralesional injection: Local hypopigmentation of deeply pigmented skin.
• Growth retardation in childn (prolonged therapy).
• Intra-articular injection: Joint damage, fibrosis esp in load bearing joints.
• Increased susceptibility for infection.
• Inhaled corticosteroids: May cause candidiasis of mouth and throat and hoarseness. 

• Thiazides may enhance hyperglycaemia and hypokalaemia caused by corticosteroids.
• Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin.
• Response to anticoagulants altered.
•  Dose of antidiabetics and antihypertensives needs to be increased.
• Decreases serum conc of salicylates and antimuscarinic agents.
• Ethanol may enhance gastric mucosal irritation.
• Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin.
• Mutual inhibition of metabolism between ciclosporin and corticosteroids increase plasma conc of both drugs.
• Enhanced effect in women taking oestrogens or oral contraceptives. Interferes with calcium absorption

Viral/fungal infections, tubercular or syphilitic lesions, bacterial infections unless used in conjunction with appropriate chemotherapy.

Store at 15-30°C. 

Molecular weight

362.4599

Molecular formula

C21H30O5

CAS number

50-23-7

Precautions

CHF, hypertension, DM, epilepsy, elderly, patients on prolonged therapy. Gradual withdrawal, pregnancy and lactation