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Hydroxyprogesterone caproate

Hydroxyprogesterone caproate, sold under the brand names Proluton, Proluton Depot, and Makena among others, is a progestin which is used in the treatment of a variety of gynecological disorders and for specific obstetric indications. More

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Description

Hydroxyprogesterone caproate, sold under the brand names Proluton, Proluton Depot, and Makena among others, is a progestin which is used in the treatment of a variety of gynecological disorders and for specific obstetric indications.

Generic Name

Hydroxyprogesterone caproate

Chemical names

Proge; Primolut Depot; Delalutin

Brand names

Anin INJ, Arisafe, Belgest Inj, Darvon, Depovig, Fetugest, Gestaur-500, Gestimax, Gynonys Inj, Higest, Hiprogress, Hpc Depot, Hylex, Hyprogres, Hyprosafe, Lgp-H, Maintane Inj, Maloxy, Novadepot, Nt-Natal, Nunest, Pregofact-H, Preto, Proeve Depot, Prolin, Prolustar Depot, Proluton Depot, Provendepot, Recogest-H, Sanigest, Zosteron

IUPAC name

(1S,2R,10R,11S,14R,15S)-14-acetyl-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,?.0¹¹,¹?]heptadec-6-en-14-yl hexanoate

Pharmacokinetics

NA

Actions

NA

Dosage/Dosage form

NA

Therapeutic uses

Hydroxyprogesterone caproate is indicated for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth. 

Adverse effects/Side effects

Allergic skin rashes, GI disturbances, weight gain or loss, increased appetite, oedema, urticaria, acne, mental depression, cough, discomfort in breast; dyspnoea, circulatory disturbances. Pain at site of injection

Interaction

Increased clearance when used with enzyme inducers e.g. Carbamazepine and Phenytoin. May inhibit metabolism of Ciclosporin.

Contraindications

Undiagnosed vaginal bleeding, breast cancer, pregnancy, lactation. Thrombophlebitis, thromboembolic disorders, cerebral apoplexy or a history of these conditions. Markedly impaired liver function.

Storage

Store at 15-30 °C.

Information

Molecular weight

428.6041

Molecular formula

C27H40O4

CAS number

630-56-8

Precautions

  • Physical examination is advised prior to starting therapy.
  • Hepatic impairment, mental depression.
  • Monitor blood glucose in diabetic patients.
  • Discontinue treatment upon signs of thromboembolic and thrombotic disorders.
  • Discontinue treatment if partial or complete loss of vision, diplopia or papilledema, protopsis, retinal vascular lesions or migraine occur.
  • Caution when used in patients with asthma, migraine, seizure disorders, cardiac or renal dysfunction.