Hydroxyzine

Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is a first-generation antihistamine.

Hydroxyzine

Hydroxyzine; Hydroxizine; Hydroxyzin; Atarax; Hydroxine

A-Rex, Adzin, Atamax, Atarax, Geozen, Glozin, H-Rax, Holzine, Hydil, Hydral, Hydroze, Hyzine, Hyzone, Krust, Myzine, Nizod, Novatrax, Oxyzen, Pru, Prugo, Psytrax, Rexzin, Roxzine, Urtivel, Xitimin, Xycotic, Zoxin

2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol

Oral absorption

Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. 

• The recommended dose is 25 mg given 3 or 4 times daily for pruritius.
•  The recommended dose is 50 to 100 mg 4 times daily for tension and anxiety.

For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. 

Blurring of vision, CNS depression, constipation, paradoxical CNS stimulation, thickened respiratory secretions, dry mouth, GI disturbances, tachycardia, hypotension, headache and tinnitus.

• Masks ototoxicity of aminoglycoside antibiotics.
• CNS depression potentiates by hypnotics, barbiturates, sedatives and neuroleptics and opioid analgesics.
• MAOIs, atropine, and TCAs potentiate antimuscarinic effects.
• Increased CNS depression with alcohol.

Porphyria, neonates, pregnancy, lactation.

Store at 15-30°C. 

Molecular weight

374.904

Molecular formula

C21H27ClN2O2

CAS number

68-88-2

Precautions

• May impair ability to drive or operate machinery.
• Asthma, bladder neck obstruction, COPD, epilepsy; hepatic and renal impairment; narrow-angle glaucoma; prostatic hypertrophy.