Idoxuridine

Idoxuridine is an anti-herpesvirus antiviral drug. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing.

Idoxuridine

Idoxuridine; 5-Iodo-2'-deoxyuridine; Idoxuridin; 5-Iododeoxyuridine

Idurin, Toxil

1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione

NA

Idoxuridine acts as an antiviral agent by inhibiting viral replication by substituting itself for thymidine in viral DNA. 

NA

For use in kerato conjunctivitis and keratitis caused by herpes simplex virus.

• Ophthalmic: Irritation; inflammation of the eye or eyelids; pain; photophobia; pruritus; conjunctivitis; oedema. Rarely, lachrymal duct occlusion and hypersensitivity reactions. Corneal damage (prolonged use).
• Topical: Hypersensitivity reactions; corneal punctate defects or skin maceration (when applied excessively).Irritation; stinging.

Corticosteroids may accelerate spread of viral infection.

Hypersensitivity.

Store between 36-80 ° F.

Molecular weight

354.0985

Molecular formula

C9H11IN2O5

CAS number

54-42-2

Precautions

• Deep ulceration of the stromal layers of the cornea.
•  Pregnancy and lactation.
• Avoid prolonged use.