Ifosfamide

Ifosfamide, sold under the brand name Ifex among others, is a chemotherapy medication used to treat a number of types of cancer.

Ifosfamide

Ifosfamide; Isophosphamide; Iphosphamide; Isofosfamide

Celofos, Fosfa, Haloxan-Uromitexan, Holoxan, Ifex-M, Ifocip, Ifomid-M, Ifoxan with Mesna INJ, Ipamide, Irnocam, Isoxan

3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2??-oxazaphosphinan-2-one

NA

NA

IV- The recommended dose is 1.2 g/m² per day for 5 consecutive days. Treatment is repeated every 3 weeks.

This is used in the treatment of cancer

Confusion, alopoecia, nausea, vomiting, phloebitis, somnolence, depression, hallucinations. Wound healing may be impaired during ifosfamide use. Nephrotoxicity, severe myelosuppression, , cardiotoxicity, haemorrhagic cystitiscoma.

• Causes enhanced toxicity with allopurinol, cisplatin.
• St John's wort may reduce its serum levels.
• Ifosfamide enhances the anticoagulant effect of warfarin.
• CYP2A6 inducers (e.g. amobarbital, pentobarbital, phenobarbital, rifampin and secobarbital) may reduce serum levels of ifosfamide while the inhibitors (e.g. isoniazid, methoxsalen and miconazole) may increase its serum levels.
• CYP3A4 inducers (e.g. phenytoin, aminoglutethimide, nafcillin, carbamazepine, nevirapine, phenobarbital, and rifamycins) may reduce serum levels of ifosfamide while the inhibitors (e.g. azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, and isoniazid) may increase its serum levels.

• Hypersensitivity; severe bone-marrow depression.
•  Pregnancy, lactation.

Store at 20-25 ?

Molecular weight

261.086

Molecular formula

C7H15Cl2N2O2P

CAS number

3778-73-2

Precautions

• Hepatic or renal dysfunction, compromised bone marrow reserve.
• This drug should be given cautiously to patients with compromised bone marrow reserve, with impaired renal function as well as to those as indicated by: leukopenia, granulocytopenia, prior radiation therapy, extensive bone marrow metastases, or prior therapy with other cytotoxic agents.