Indapamide

Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure.

Indapamide

Indapamide; Noranat; Veroxil; Tertensif

Atelol-D, Aten-D, Cgmide, Coversyl Plus, Diurix, Divret, Eviper-D, Fanton, In-SR, Inat, Ind-SR, Indacard, Indact, Indact-SR, Indap, Indap-AT, Indicontin, Inzu, Lorvas, Natrilix, Nebula-D, Perifer, Perigard-D, Perigard-DF

4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide

Oral absorption.

Indapamide is an antihypertensive and a diuretic activity because this drug contains both a lipid- soluble methylindoline moiety and a polar sulfamoyl chlorobenzamide moiety. Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. This drug probably inhibits the passage of other ions (sodium, potassium) and calcium across membranes, appears to cause vasodilation, this same effect may cause hypokalcemia in susceptible individuals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

1.25-2.5 mg once daily for hypertension.

Used in the treatment of hypertension, as well as decompensated cardiac failure.

Headache, dizziness, weakness, drowsiness, fatigue, agitation, nervousness, anorexia, nausea, vomiting, pain, diarrhoea, constipation, orthostatic hypotension, palpitations, hypokalaemia, hyponatraemia, metabolic alkalosis.

• Hypokalaemia enhances digitalis toxicity with cardiac gycosides.
• Increased risk of lithium toxicity.
• Additive effect with other diuretics and antihypertensive agents.
• Increased chance of hypokalaemia with corticotrophin, corticosteroids and amphotericin.

Anuria, severe hepatic impairment

Store at 20-25°C.

Molecular weight

365.835

Molecular formula

C16H16ClN3O3S

CAS number

26807-65-8

Precautions

• Uric acid and potassium serum levels will be monitor, especially in patients with gout and in patients with a sensitivity or predisposition to hypokalemia.
• Pregnancy, lactation, elderly, renal impairment, fluid or electrolyte imbalance, hyperuricaemia, DM, lupus erythematosus.