Indinavir

Indinavir is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS.

Indinavir

Indinavir; Crixivan; Compound J; MK-639

Inbec, Inbed, Ind, Indease, Indivan, Indivir, Virodin

(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide

Oral absorption.

Indinavir inhibits the HIV viral protease enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.

The recommended dose is 800 mg 8 hourly orally.

Indinavir is an antiretroviral drug prescribed for the treatment of HIV infection.

Flank pain, abdominal pain, nephrolithiasis, malaise, nausea, vomiting, diarrhoea, elevated liver enzymes, hyperbilirubinaemia, raised creatinine phosphokinase and blood lipids, back pain, lipodystrophy, alopecia, acid regurgitation, dyspepsia, dry mouth, dysuria, dry skin, hyperpigmentation, headache, dizziness, somnolence, cough, dyspnoea.

• Increased risk of cardiac arrhythmias with amiodarone, pimozide or cisapride.
•  Increased sedation and respiratory depression with midazolam, alprazolam and triazolam.
•  Increased risk of ergotism with ergot derivatives.
• Increased toxicity of drugs with narrow therapeutic index.
• Reduced absorption with antacids. Increased concentrations with ketoconazole, delavirdine, nelfinavir and ritonavir.
• Reduced efficacy with nevirapine, efavirenz or rifampicin.
• Increased risk of myopathy with statins.
• Reduced concentrations with grapefruit juice.
• Reduced antiviral response with St. John's wort.
• Increased concentrations of phosphodiesterase-5 inhibitors.

Hypersensitivity. Severe hepatic impairment.

Store at 15-30°C

Molecular weight

613.7895

Molecular formula

C36H47N5O4

CAS number

150378-17-9

Precautions

• Increased risk of urolithiasis/nephrolithiasis.
• Ensure adequate hydration.
• Hyperbilirubinaemia may be exacerbated.
• Diabetes; haemophilia.
• Monitor for signs of lipodystrophy.
• Pregnancy and lactation.