Insulin

It is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the main anabolic hormone of the body.

Insulin

8a-L-threonine-10a-L-isoleucine-30b-L-serine

Actrapid, Actrapid Flexpen, B-D Micro-Fine, Basalog, Bovine Fastact, Bovine Longact, Bovine-Mixact, Humalog, Human Actrapid, Human Fastact, Human Insulatard, Human Insunorm, Human Longact, Human Mixact, Human Mixtard, Human Mixtard 50, Human Monotard, Human Prodica, Human Rapidica, Human Rapimix, Human Zinulin, Human-Mixact, Humanext-N, Humapen, Huminsulin 30/70, Huminsulin 50:50, Huminsulin-L, Huminsulin-N, Huminsulin-R, Humstard, Humstard 30/70, Iletin-N, Iletin-R, Insucare-M 30, Insucare-M 50, Insucare-N, Insucare-R, Insugen-30/70, Insugen-50/50, Insugen-N, Insugen-R, Insulatard, Insulatard HM Penfill, Insulatard Novolet, Insulatard-HM, Insuman 25/75, Insuman 50/50, Insuman Basal, Insuman Rapid, Insuman-Comb.

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SC- Usual range: The recommended dose is 0.5 to 1 u/kg/day.

This medication is a fast-acting form of the hormone insulin, prescribed for diabetes mellitus. 

Headache, neuropathy, seizure, sensory disturbances. Diabetic retinopathy, nasopharyngitis. Lipodystrophy (from repeated insulin injection into same site), pruritus, rash, skin disorder. Accidental injury, chest pain, hyporeflexia, influenza, onychomycosis, peripheral edema.

• Possible absence of hypoglycemic warning symptoms with b blockers.
• Decreased hypoglycemic effect with corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, phenothiazine derivatives, somaropin, sympathomimtic reagents, thyroid hormones, oestrogens, progestins (e.g. in ral contraceptives), protease inhibitors and atypical antipsychotic (e.g. olanzapine and clozapine).
• Hypoglycaemic effect will be increased with ACE inhibitors, oral antidiabetic agents, disopyramide, fluoxetine, fibrates, MAOIs, propaxyphne, pentoxifylline, salicylates and sulfonamide antibiotics.
• Decreased insulin resistance with octreotide and lanreotide.
• Increased risk of weight gain and peripheral oedemawith pioglitazone, rosiglitazone.
• Decreased effect of sermorelin.

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Molecular weight

5808.0 Da

Molecular formula

C257H383N65O77S6

CAS number

NA

Precautions

• Check blood sugar frequently and observe for signs of hypoglycemia and hyperglycemia.
• Check potassium levels closely when administering IV. Periodically measure glycosylated hemoglobin (A 1c) to monitor long-term glycemic control.
• Check urine for ketones in patients at risk for ketoacidosis and observe for signs and symptoms of ketoacidosis (eg, drowsiness, frequent urination, fruit-like breath, thirst).