It is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. More
It is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
Irbesartan
Irbesartan; Aprovel; Avapro; Karvea
Aprovel, Coaprovel, Irbest, Irovel, Irovel-H, Xarb, Xarb-H
2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one
NA
NA
It comes as a tablet to take by mouth.
For the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. This is also used in the treatment of congestive heart failure as a second line agent.
Diarrhoea, dizziness, fatigue, headache, hyperkalaemia. Dyspepsia, oedema, myalgia, insomnia, nasal congestion, 1st dose orthostatic hypotension, rash, pharyngitis, urticaria, angioedema, anxiety/nervousness, tachycardia.
Potassium or potassium-sparing diuretics may increase risk of hyperkalaemia. NSAIDs may reduce antihypertensive response. Excretion of lithium may be reduced, monitor lithium concentrations.
Hypersensitivity; pregnancy and lactation
Store at 25°C.
428.5294
C25H28N6O
138402-11-6
Child <6 years. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy.
