Irinotecan

It is a medication used to treat colon cancer and small cell lung cancer.

Irinotecan

Irinotecan; Camptosar; (+)-Irinotecan; Irinotecanum

Campto, Colotecan, Irinot, Irinotel, Irnocam, Rinotec, Torsirin

(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0?,?.0¹?,²?]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate

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IV- The recommended dose is 125mg/ m² over 90 minutes infusion, weekly for 4 weeks followed by a gap of 2 weeks.

Used for the treatment of cancer.

Lachrymation, anaemia, neutropenia, acute diarrhoea, thrombocytopenia; sweating, abdominal cramps, hypersalivation, miosis, weakness; vomiting, nausea, alopecia and skin reactions; cardiovascular toxicity.

• St John's wort
• Diuretics may increase the risks of vomiting/diarrhoea to secondary dehydration;
• Prophylactic dexamethasone as an antiemetic may enhance lymphocytopenia;
• Prochlorperazine may increase incidence of akathisia; antineoplastic agents (myelosuppression and diarrhoea).
• Ketoconazole may reduce irinotecan exposure.

• Pregnancy and lactation.
• Inflammatory bowel disease, severe hepatic impairment, bowel obstruction. 

Store it at controlled room temperature (15° to 30°C)

Molecular weight

586.678

Molecular formula

C33H38N4O6

CAS number

97682-44-5

Precautions

• Avoid use of laxatives because of the risk of increased diarrhea. 
• Avoid extravasations.