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Iron sucrose

It is an iron replacement product, is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use. More

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Description

It is an iron replacement product, is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use.

Generic Name

Iron sucrose

Chemical names

Iron sugar; Saccharated iron; Sucroferric oxyhydroxide; Saccharated iron oxide; Saccharated ferric oxide

Brand names

Addfer, Amvi, Aviron, Axifer, Bredium, Carbifol INJ, Cerelac Stage-2, Cerelac Stage-2 Wheat, Honey, Cerelac Stage-3, Cerelac Stage-4, Coheam, Corus, Evron, Farris INJ, Feristar, Ferocorp, Feroject, Feropic Inc, Ferosig INJ, Ferrosys Inj, Feshia, Fesu, Fezza-S, Fludoxin, Globac Safe, Haemglow Inj, Hembeec-IS, Hemilift, Icor-100, Icor-50, Intrafer, Ircor, Iro-Jet, Irofer-XT, Irozorb-S, Isest, Jalika, Lactogen-2, Litron INJ, Microfer, Moran, Nepro-HP, Nepro-LP, Nicofer, Nurox, Omron, Quron, Redbury INJ, Redfed Inj, Rirone-SE

IUPAC name

pentairon(3+) ion disodium (2R,3R,4S,5S,6R)-2-{[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol trihydrate hydroxide octaoxidandiide

Pharmacokinetics

NA

Actions

NA

Dosage/Dosage form

IV- The recommended dose is 1000 mg over 2 to 5 minutes infusion, in divided doses within 2 weeks time.

Therapeutic uses

Iron sucrose is elemental iron as an injection. It replenishes body iron stores in patients with iron deficiency.

Adverse effects/Side effects

Muscle cramp, diarrhea, vomiting, nausea, headache, hypotension, dizziness, pruritus, chest pain, pain in extremity, arthralgia, back pain, injection site reactions, and peripheral edema.

Interaction

Iron sucrose may prevent the absorption of oral iron formulation such as ferrous sulfate, ferrous fumarate and ferrous gluconate.

Contraindications

Iron sucrose is contraindicated in patients with iron allergy, hemochromatosis, hepatitis, hypotension and history of many blood transfusions.

Storage

Store at 20-25°C.

Information

Molecular weight

866.546

Molecular formula

C12H29Fe5Na2O23

CAS number

8047-67-4

Precautions

Precautions with hypersensitivity reactions, hypotension and Iron overload.