Isoniazid

Also known as isonicotinylhydrazide (INH), is an antibiotic used for the treatment of tuberculosis.

Isoniazid

Isoniazid; Isonicotinic acid hydrazide; Isonicotinohydrazide; 54-85-3; Pyridine-4-carbohydrazide

Myconx-800, 3-Fd, 4-D, 4-D Plus, Acrifa, Acrifa Forte, Acrifa Plus, Acrifa-DS, Afb3, Afb4, Akt-2, Akt-3, Akt-4, Akt-FD, Akurit, Akurit Kid, Akurit-3, Akurit-4, Akurit-Z, Akurit-Z Kid, Antibin, Antibin-Kid, Arzade, Becox, Becox Forte, Becox-RH, Bicox Kid, Bicox Kid Forte, Bicox-600, Bicox-E, Bicox-Kid 50, Binex, Binex Kid, Binex-DT, Binex-E, Binex-Z, Binex-ZE, Bionex Plus, Cavidin-INH, Cavirip-1000, Caviter, Caviter-FD, Caviter-RHE, Combunex, Confez-3, Coxcure-4, Coxina-3, Coxina-4, Coxinex, Coxkit-3

pyridine-4-carbohydrazide

Oral absorption

It is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a highly specific agent, ineffective against other microorganisms. 

5mg/kg up to 300 mg daily in a single dose; or 15 mg/kg up to 900 mg/day, two or three times/week. 

For the treatment of all forms of tuberculosis in which organisms are susceptible.

Fever, optic neuritis; convulsions, psychotic reactions, nausea, fatigue, vomiting, visual disturbances, epigastric distress, rash, and pyridoxine deficiency. Hepatotoxicity. Peripheral neuritis.

• May increase metabolism of enflurane resulting in nephrotoxic fluoride levels.
• May increase toxicity of chlorzoxazone, carbamazepine, clofazimine, chlorzoxazone, ethosuximide, diazepam & triazolam, phenytoin, theophylline, theophylline, cycloserine & warfarin.
• Reduced efficacy & increased risk of peripheral neuropathies & hepatotoxicity with alcohol.
• Reduced absorption with aluminium- containing antacids; give at least one hour before the antacid.
• Decreased serum levels with ketaconazole zalcitabine.
• Increased risk of hepatotoxicity with rifampicin and other drugs. 

Acute liver disease or history of hepatic damage during INH therapy; hypersensitivity.

Store at 59°-86° F (15°-30° C).

Molecular weight

137.1393

Molecular formula

C6H7N3O

CAS number

54-85-3

Precautions

• Renal or hepatic impairment
• Careful monitoring of hepatic function is necessary for black & Hispanic women.
• Convulsions disorders; history of psychosis; patients at risk of neuropathy or pyridoxine deficiency e.g. Diabetic, alcoholic, malnourished, uraemic, infected with HIV.
• Check hepatic function before & during treatment.
• Pregnancy & lactation.