Isoprenaline or Isoproterenol

It is a medication used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma.

Isoprenaline or Isoproterenol

Isoproterenol; Isoprenaline; Isoprenalin; Norisodrine; Novodrin

Autohaler, Isolin, Isoprin, Isosol, Neo- Epinine, Neo-Epinine

4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol

NA

NA

IV- The recommended dose range is 0.01mg to 0.06mg.

For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis.

Nervousness, restlessness, insomnia, anxiety, tension, blurring of vision, fear, excitement. Rarely, sweating, weakness, pallor, dizziness, mild tremor, headache, flushing of the face or skin, nausea, vomiting, tinnitus, lightheadedness, asthenia. Swelling of the parotid glands (prolonged use). Pulmonary oedema, dyspneoa. Palpitation and ventricular tachycardia. Transient myocardial ischaemia or myocardial dysfunction in children.

• Severe arrhythmias may occur with epinephrine, digitalis, cyclopropane, halogenated hydrocarbon anaesthetics.
• Additive peripheral vasoconstriction may occur with ergot alkaloids. Cardiac, bronchodilating and vasodilating effects may be antagonised by β-blockers e.g. propranolol.

• Tachycardia or heart block due to digitalis intoxication
• Tachyarrhythmia’s
• Ventricular arrhythmias which require inotropic therapy
•  Angina pectoris.

Store at controlled room temperature 20-25°C 

Molecular weight

211.2576

Molecular formula

C11H17NO3

CAS number

7683-59-2

Precautions

• Coronary artery disease, coronary insufficiency, diabetes, hyperthyroidism.
• Pregnancy and lactation.
•  Parenteral: May paradoxically worsen heart block or precipitate Adams
• Stokes attacks during normal sinus rhythm or transient heart block.
• Caution in patients with failing heart or in those with significant degree of arteriosclerosis.
• Monitor response to therapy by frequent determination of the central venous pressure and blood gases.
• Ensure adequate ventilation.
• Monitor acid-base balance and correct any electrolyte disturbances.
• Inhalation: Severe paradoxical airway resistance may occur with repeated and excessive use.
• Carefully instruct the patient in the proper technique of admin.