Isosorbide dinitrate

It is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart.

Isosorbide dinitrate

ISOSORBIDE DINITRATE; Sorbide nitrate; Sorbidnitrate; Isordil

Anzidin, Cardicap, Isolazine, Isordil, Olvisol, Sorbitrate

(3S,3aS,6R,6aS)-6-(nitrooxy)-hexahydrofuro[3,2-b]furan-3-yl nitrate

Hepatic metabolism.

Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Arteriolar relaxation reduces systolic arterial pressure, systemic vascular resistance, and means arterial pressure.

20-120 mg daily in divided doses for the management of angina. 

For the prevention of angina pectoris due to coronary artery disease.

Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Apprehension, restlessness, weakness and vertigo.

• Vasodilatory effect may be reduced with dihydroergotamine.
• Increased hypotensive effects with alcohol or vasodilators.
• Marked orthostatic hypotension may occur when used with calcium channel blockers.
• Significant hypotension may occur with phosphodiesterase-5 inhibitors.
• Ergotamine effects may be enhanced.
• Effectiveness may be reduced by sublingual form of disopyramide.

Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage.

Store at room temperature (25°C)

Molecular weight

236.1363

Molecular formula

C6H8N2O8

CAS number

87-33-2

Precautions

Raised intracranial pressure, hypotension, hypovolaemia. Arterial hypoxaemia, glaucoma, hypothyroidism, elderly, malnutrition, pregnancy, lactation. Mitral valve prolapsed.