Isosorbide mononitrate

It is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

Isosorbide mononitrate

ISOSORBIDE MONONITRATE; Isosorbide 5-mononitrate; Monosorbitrate; 16051-77-7; Imdur

5-Mono, Abitrate, Abitrate-SR, Angicor, Anginex, Angitab, Angitrit, Aspitrate, Cusor, Cusor-ER, Diltrate, Ecosmin, IHD, Imdur, Imnit, Ismo, Ismo Retard, Ismorin, Isoact, Isocor-20, Isomin-20, Isonorm, Isonorm-SR, Isotop, Monet, Monicor, Monit, Monit-AS, Monn, Mono-A, Mono-Isordil, Monocontin, Monomen-20, Monopark, Monosorbitrate, Monosprin, Monotrace, Monotrate, Monotrate Od, Monotrate-SR, Nican-CR, Nitren, Nitrofix, Nitrofix-AS, Nitroprin, Nitrovas SR, Olvisol, Olvisol-SR, Solosprin, Solotrate

(3R,3aS,6S,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl nitrate

Oral absorption and hepatic metabolism.

Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.

20 mg 2-3 times daily. Dose may range from 20-120 mg daily.

For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.

Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Restlessness, weakness and vertigo. Dry mouth, chest pain, back pain, oedema, fatigue, abdominal pain, constipation, diarrhoea, dyspepsia and flatulence.

• Significant hypotension may occur when used with phosphodiesterase-5 inhibitors.
• Hypotensive effects may be increased when used with alcohol or vasodilators.
• Concurrent use with calcium channel blockers may lead to marked orthostatic hypotension.

• Hypovolaemia,
•  Heart failure due to obstruction,
• Severe hypotension or anaemia
• Raised intracranial pressure due to cerebral haemorrhage or head trauma.

Store at 20-25°C.

Molecular weight

191.1388

Molecular formula

C6H9NO6

CAS number

16051-77-7

Precautions

• Caution in patients who are already hypotensive.
• Severe hepatic or severe renal impairment
•  Malnutrition, hypothyroidism, or hypothermia.
• May aggravate angina caused by hypertrophic cardiomyopathy.
• Tolerance may develop after long-term treatment.
•  Lactation.