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Kanamycin-is an antibiotic used to treat severe bacterial infections and tuberculosis.

Kanamycin A, often referred to as simple kanamycin, is an antibiotic used to treat severe bacterial infections and tuberculosis. It is not a first line treatment. It is used by mouth, injection into a vein, or injection into a muscle. More

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Description

Kanamycin A, often referred to as simple kanamycin, is an antibiotic used to treat severe bacterial infections and tuberculosis. It is not a first line treatment. It is used by mouth, injection into a vein, or injection into a muscle.

Generic Name

Kanamycin-is an antibiotic used to treat severe bacterial infections and tuberculosis.

Chemical names

Kanamycin, Kanamycin Base, Kanamycinum

Brand names

Efficin, Kanamac, Kanamycin, Kancin, Neokanyn, Tiniba INF

IUPAC name

(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-3-{[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}oxane-3,4,5-triol

Pharmacokinetics

Actions

Dosage/Dosage form

The recommended dose is 500 mg to 1g per day in divided doses as IV/IM route.

Therapeutic uses

Prescribed for serious bacterial infections.

Adverse effects/Side effects

Pain, inflammation, bruising, haematoma at inj site; GI disturbances; malabsorption of fat. Potentially Fatal: Neuromuscular blockade; nephrotoxicity; ototoxicity.

Interaction

  • Synergistic effects with ampicillin, benzylpenicillin and other β-lactam antibiotics.
  • May reduce renal excretion of zalcitabine.
  • Increased risk of ototoxicity with ethacrynic acid and furosemide.
  • Increased risk of nephrotoxicity with cisplatin, cephalosporins, vancomycin, ciclosporin, hydrocortisone and indomethacin.
  • Potentiates effects of neuromuscular blocking agents.

Contraindications

Hypersensitivity. GI ulceration

Storage

Store at 20-25 ?

Information

Molecular weight

484.4986

Molecular formula

C18H36N4O11

CAS number

59-01-8

Precautions

Renal impairment, dehydration, previous exposure to ototoxic drugs; preexisting tinnitus, vertigo or subclinical hearing loss. Parkinsonism, myasthenia gravis. Infants, neonates, elderly. Pregnancy, lactation. It should not be used on long treatment.