Ketoprofen-nonsteroidal anti-inflammatory drug (NSAID)

Ketoprofen works by blocking the effect of chemicals called cyclo-oxygenase (COX) enzymes; more about relieving pain with ketoprofen.

Ketoprofen-nonsteroidal anti-inflammatory drug (NSAID)

Ketoprofen; 2-(3-Benzoylphenyl)propanoic acid; 2-(3-Benzoylphenyl)propionic acid; Ketoprofene

Fastum Gel, Ketofen, Ketonal-D, Ketopatch, Lupiflex, Maxigesic Plus, Myoril Plus, Ostofen, Redufen, Redufen-A, Relyonketo, Rhofenid, Rhofenid Gel, Vofane

2-(3-benzoylphenyl)propanoic acid

• Absorption: oral
• Distribution: 99%
• Metabolism: Liver
• Excretion: Urine

Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. 

25 to 300 mg per day in divided doses.

Analgesic and antipyretic effects. Ketoprofen is used to treat osteoarthritis, rheumatoid arthritis, dysmenorrhea, and alleviate moderate pain.

Acute interstitial nephritis, reversible decline in renal function; GI symptoms e.g. discomfort, nausea, diarrhoea; pain and tissue damage at injection site (IM). Potentially Fatal: Rarely, idiosyncrasy, anaphylaxis; very rarely GI haemorrhage.

• Risk of nephrotoxicity increased with ACE inhibitors, ciclosporin, tacrolimus or diuretics.
• Increased risk of hyperkalaemia with ACE inhibitors and potassium-sparing diuretics.
• Reduces effects of antihypertensives (e.g. ACE inhibitors, β-blockers).
• Increased risk of convulsions with quinolones.
• Increased risk of adverse effects with aspirin.
• Increased risk of ulceration and GI bleeding with SSRIs, corticosteroids, clopidogrel and ticlopidine.
• Increased risk of haematotoxicity with zidovudine.
• May alter the efficacy of mifepristone.
• Increased plasma levels with probenecid.
• Enhances effects of oral anticoagulants, phenytoin and sulfonylureas.
• Increases plasma concentrations of lithium, methotrexate and cardiac glycosides.

• Acute or history of peptic ulcer or dyspepsia.
• Hypersensitivity to NSAIDs or those suffering from bronchial asthma, angioedema, urticaria or rhinitis. Severe renal insufficiency.

15-30 ?

Molecular weight

254.2806

Molecular formula

C16H14O3

CAS number

22071-15-4

Precautions

• Pregnancy, lactation.
• Renal or hepatic impairment.
• Elderly.
• Heart failure.