Nalbuphine

is a semi-synthetic opioid agonist-antagonist used commercially as an analgesic under a variety of trade names, including Nubain and Manfine.

Nalbuphine

Nalbuphine; Nalbuphinum; Nalbufina; 20594-83-6; Nubain

Nalfy, Ruffy

(1S,5R,13R,14S,17S)-4-(cyclobutylmethyl)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0?,¹?.0?,¹?]octadeca-7,9,11(18)-triene-10,14,17-triol

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IV/IM/SC- The usual recommended adult dose is 10 mg for a 70 kg individual.

For the relief of moderate to severe pain such as post-surgery pain and labor pain.

Speech difficulty, urinary urgency, depression, blurred vision, flushing and warmth, nervousness, restlessness, elevated mood, crying, hostility, floating, unusual dreams, confusion, faintness, hallucinations, anxiety, feeling of heaviness, numbness, tingling. 

• Alcohol consumption may boost the adverse events of nalbuphine.
• Avoid concomitant treatment of Nalbuphine with sedatives, anti-histamines, narcotic pain relievers, muscle relaxants, anxiolytics, anti-convulsants, anti-depressants and hypnotics.
• Other drugs may interact with nalbuphine such as methadone, oxycodone, fentanyl, morphine, hydrocodone, codeine and hydromorphone.

COPD, traumatic head injury, liver or kidney diseases, brain tumor, asthma, sepsis, gallbladder diseases and psychiatric disorders. 

Store at 25°C.

Molecular weight

357.4434

Molecular formula

C21H27NO4

CAS number

20594-83-6

Precautions

The drug should not be prescribed to patients with substance/alcohol abuse. Nalbuphine treatment may results in addiction.