Sold under the brand name Narcan among others, is a medication used to block the effects of opioids, especially in overdose.
Naloxone
Naloxone; L-Naloxone; 465-65-6; N-Allylnoroxymorphone; (-)-Naloxone
Nalox, Narcotan, Nex, Qudict
(1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
NA
NA
The recommended dose is 0.4- to 0.8mg, IV, repeat if needed at 2-3 min intervals. Consider over dosage with other drugs if there is no response after a total of 10 mg has been given.
For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol. It is also indicated for the diagnosis of suspected acute opioid overdose. It may also be used as an adjunctive agent to increase blood pressure in the management of septic shock.
Severe cardiopulmonary effects (e.g. hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnoea, pulmonary oedema, cardiac arrest) in postoperative patients, most frequently in those with preexisting CV disease. Recurrence of respiratory depression in long-acting opioids.
Hypersensitivity
Store at 25°C.
327.3743
C19H21NO4
465-65-6
Patients physically dependent on opioids, or who have received large doses of opioids (acute withdrawal syndrome may be precipitated). Pregnancy and lactation.
