Naproxen

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class that relieves pain, fever, swelling, and stiffness.

Naproxen

(S)-Naproxen; Naprosyn; Naproxene

Antesvel, Artagen, Arthopan, Headset, Movibon, Napexar, Napra-D, Napra-S, Napris, Naprodom, Naprosyn, Naprosyn Gel, Naprosyn Susp, Naprosyn-P, Napryn, Naxdom, Naxen, Pacinac-NP, Spirox, Spirox-D, Suminat Forte, Suminat Plus, Xenadom, Xenar-CR, Xenobid Gel, Xenobid Tab

(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid

Absorbed from the GI tract with an in vivo bioavailability of 95%. 

Naproxen is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen has analgesic and antipyretic properties.

PO- 0.5-1 g in 1-2 divided doses, upto 6 months if needed. Up to 1.5 g/day in patients who can tolerate lower doses.

For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout, primary dysmenorrhea.

Oedema, palpitation, dizziness, drowsiness, headache, light headedness, vertigo, pruritus, skin eruption, ecchymosis, purpura, rash, fluid retention, abdominal pain, constipation, nausea, heartburn, diarrhoea, dyspepsia, stomatitis, flatulence, gross bleeding/perforation, indigestion, ulcers, vomiting, abnormal renal function, haemolysis, anaemia, increased bleeding time, elevated LFTs, visual disturbances, tinnitus, hearing disturbances, dyspnoea, diaphoresis, thirst.

• Antihypertensive effects of hypotensive agents may be reduced.
• May increase ciclosporin levels.
• Increased risk of seizures with fluoroquinolones.
• May reduce efficacy of diuretics.
• May diminish the cardioprotective effect of acetylated salicylates.
• Increased risk of GI ulceration with corticosteroids.
• May increase lithium levels/toxicity.
• With methotrexate aplastic anaemia, severe bone marrow suppression and GI toxicity may occur.
•  Increased risk of bleeding with anticoagulants (e.g. warfarin, heparin, LMWHs) and antiplatelet agents (e.g. ticlopidine, clopidogrel, aspirin, abciximab, dipyridamole, eptifibatide, tirofiban).
• Rate of absorption may be reduced with food. Avoid herbs/food with antiplatelet activity e.g. ginseng, bilberry, grapeseed, bromelain, turmeric, cat's claw, coleus, celery, cordyceps, dong quai, alfalfa, evening primrose, feverfew, fenugreek, green tea, garlic, ginger, red clover, bladderwrack, horse chestnut, ginkgo biloba, guggul, horse chestnut seed, anise, horseradish, licorice, prickly ash, reishi, sweet clover, white willow.
• Absorption may be reduced with colestyramine (and other bile acid sequestrants).
• Alcohol may enhance gastric mucosal irritation.
• Increased serum levels with probenecid.

Hypersensitivity. Aspirin or NSAID allergy. Perioperative pain in the setting of CABG surgery. Pregnancy (3rd trimester)

Store at 15-30°C (59-86°F).

Molecular weight

230.2592

Molecular formula

C14H14O3

CAS number

22204-53-1

Precautions

• Pre-existing CV risk factors or disease e.g. fluid retention, CHF, hypertension. History of GI disease (bleeding or ulcers).
• Other forms of asthma.
• Hepatic impairment; closely monitor patients with any abnormal LFT.
• Renal impairment.
•  Elderly.
• Lactation.