Nicotine

Nicotine

Nicotine, L-Nicotine, (-)-Nicotine, (S)-Nicotine

Nicoderm CQ, Nicorette, Nicotrol Inhaler, Nicotrol NS

3-(1-methylpyrrolidin-2-yl) pyridine

It is absorbed through buccal mucosa, metabolized through lungs, liver and kidneys. Excreted unchanged in urine.

Nicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. 

• Patch: One for 16 or 24 hours hours daily applied to dry, hair, free skin on the hip, trunk or upper arm for smoking cessation.
• Inhalator: Inhale with 10 mg/cartridge nicotine
• Nasal spray: 1 spray of 500 mcg administered into each nostril
• Chewing gum: 2-4 mg gum

Smoking cessation 

Nausea, myalgia, hiccups, abnormal hunger, dysmenorrhoea, rash, cold, headache, and flu like symptoms.

Nicotine increases hemodynamic & AV blocking effects of adenosine 

Contraindicated during pregnancy and lactations, contraindicated in geriatrics, children’s, and in patients of acute MI, cerebrovascular accident, severe cardiac arrhythmias, unstable or worsening angina pectoris, active temporomandibular joint disease.

Protect from light, 68° to 77°F

Molecular weight

162.236 g/mol

Molecular formula

C10H14N2

CAS number

54-11-5

Precautions

Use with caution in patients of CV disease, myasthenia gravis, skin diseases, oropharyngeal inflammation.