Octreotide-It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.

Octreotide is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin

Octreotide-It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.

Octreotide; Octreotidum [Latin]; Octreotide-LAR; Octreotide Acetate Salt, Octreotida [Spanish]

Actide, Octate, Ferotide, Octide, Octreo,Octotide, Octride, Okeron, Octronis, Otide, Sandostatin Lar, Sandostatin

(4R,7S,10S,13R,16S,19R)-19-[(2R)-2-amino-3-phenylpropanamido]-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-[(1H-indol-3-yl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17

Octreotide binds to somatostatin receptors. Octreotide binding to these receptors stimulates phosphotyrosine phosphatase and activation of the Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins and coupled via pertussis toxin sensitive G proteins which lead to inhibition of adenylyl cyclase. 

The recommended dose is 50-100 mcg twice a day as SC route, dose may increase up to 500 mcg. 

For treatment of acromegaly and reduction of side effects from cancer chemotherapy

Local pain, stinging, tingling at site of inj; anorexia, nausea, vomiting, abdominal pain, bloating, flatulence, loose stools, steatorrhoea; biliary tract abnormalities. Hypoglycaemia and hyperglycaemia, hypothyroidism, cardiac conduction abnormalitles, pancreatitis.

• Dosage adjustment of concurrent therapy may be necessary with calcium channel blockers, oral hypoglycaemics, β-blockers, diuretics.
• Requirements of insulin may be reduced requiring careful blood-glucose monitoring. Reduction in ciclosporin bioavailability and efficacy.
• May increase concentration of bromocriptine.
• Schedule injections between meals to decrease adverse GI effects.

Stable at room temperature for up to 14 days. Store at 2-8°C.

Molecular weight

1019.25

Molecular formula

C49H66N10O10S2

CAS number

83150-76-9

Precautions

• Monitor levels of vitamin B12 during long term therapy.
• DM
• Renal disease; risk of gall bladder disease.
• Hypothyroidism
• Pregnancy, lactation, children, elderly.