Ofloxacin-antibiotic useful for the treatment of a number of bacterial infections.

Ofloxacin is given to treat a bacterial infection. It is useful for treating infections such as chest infections , urine infections , skin and soft tissue

Ofloxacin-antibiotic useful for the treatment of a number of bacterial infections.

Ofloxacin; Floxin; Ofloxacine; Tarivid

A-Flox, A-Flox-M, A-Flox-OZ, Ab-Fax-OX, Abflox, Abflox Dps, Abflox-D Dps, Abflox-O, Abof, Abof-Nz, Abof-OZ, Acoflox, Acoflox-OZ, Acoflox-TZ, Activid, Actvid, Adeflox-O, Aeroflox, Aflox, Aflox-OZ, Agiflo-OZ, Agroflox, Agroflox-M, Agroflox-OZ, Alocin, Alocin Tab, Alocin-Kid, Alocin-OZ, Alof, Aloflox, Aloflox-ON, Alox, Alox-Od, Alproxen, Altoxin, Altoxin-Oz, Ando, Ando-NZ, Ando-OZ, Anti, Anti-Oz, Antof, Antof-OZ, Ariflox, Ariflox-Oz, Arilif-Oz, Arlox, Armbid, Armbid-NT

7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0?,¹³]trideca-5(13),6,8,11-tetraene-11-carboxylic acid

98% bioavailability, 32% protein binding, hepatic metabolism and renal excretion.

Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, it is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required replicating one DNA double helix into two. 

The recommended dose is 200-800 mg/day in divided doses as PO.

For the treatment of respiratory tract, kidney, skin, soft tissue, UTI infections, urethral and cervical gonorrhoea.

Nausea, vomiting, abdominal pain, diarrhoea; headache, dizziness, insomnia, hallucinations; leucopenia and eosinophilia; vaginitis; dysgeusia; tendon damage and rupture; anorexia; tremor; photosensitivity; hypersensitivity reactions. Discontinue if psychiatric, neurological or hypersensitivity reactions occur.

• Corticosteroids may increase risk of tendon rupture. Increases effects of oral anticoagulants, ciclosporin, theophylline.
• Antacids may reduce ofloxacin absorption, avoid for 2 hr either side of administration.
• Increased risk of seizures with NSAIDs.
• Probenecid decreases elimination.
• Avoid in patients taking QT prolonging medication (e.g. class Ia or III antiarrythmics, astemizole, terfenadine, cisapride, erythromycin, pentamidine, phenothiazines and some TCA).
• Cimetidine may increase ofloxacin concentrations.
• Monitor blood glucose in patients on antidiabetic medication.

Hypersensitivity to quinolones; pregnancy and lactation; prolongation of the QT interval; uncorrected hypokalaemia.

Store at 15-25°C. 

Molecular weight

361.3675

Molecular formula

C18H20FN3O4

CAS number

82419-36-1

Precautions

• Epilepsy or other predisposition to seizures; known or suspected CNS disorders; renal, hepatic impairment; myasthaenia gravis; superinfection; children <18 yr; exposure to strong sunlight and UV light; ensure adequate hydration; elderly.
• Adequate hydration of patients receiving ofloxacin should be maintained to prevent the formation of highly concentrated urine.