Olanzapine-an atypical antipsychotic.

Olanzapine is one of those second generation antipsychotics approved for the treatment of schizophrenia and bipolar disorder.

Olanzapine-an atypical antipsychotic.

Olanzapine; Zyprexa; Zyprexa Zydis; Olansek

Anzatric, Cinol, Cinol Forte, Cinol Plus, Dopin Tab, Dopin-F, Fostera, Jolyon-MD, Joyzol, Lano, Lanopin, Lezapin-MD, M-Olan, M-Olan Plus, Manza, Meltolan, Odozap, Olace, Oladay, Oladay-F, Olan, Olancare, Olandus, Olanex, O

5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0³,?]tetradeca-1(14),3(7),5,8,10,12-hexaene

Olanzapine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. 

5-10 mg daily

For the treatment of schizophrenia and related psychotic disorders

Postural hypotension; constipation; dizziness; wt gain; agitation; insomnia; akathisia; tremor; personality disorders; oedema; somnolence; increased appetite; antimuscarinic effects; speech difficulty; exacerbation of Parkinson's disease; hallucinations; asthenia; increased body temperature; hyperprolactinaemia; bradycardia; asymptomatic elevations of hepatic transaminases.

• Olanzapine may antagonise the effects of levodopa and dopamine agonists.
• Drugs that induce CYP1A2 or glucuronyl transferase enzymes e.g. omeprazole and rifampicin, may increase olanzapine clearance.
• Inhibitors of CYP1A2 may potentially inhibit olanzapine elimination.
• Carbamazepine may increase the clearance of olanzapine.
• Concomitant admin of activated charcoal reduced the oral bioavailability of olanzapine by 50-60%.
• Caution should be taken when olanzapine is administered with centrally acting drugs and alcohol.

Angle-closure glaucoma; lactation. IM: History of CVS disease, heart surgery.

Store at 15-30°C. 

Molecular weight

312.432

Molecular formula

C17H20N4S

CAS number

132539-06-1

Precautions

• Impaired hepatic, renal, cardiovascular function; paralytic ileus; prostatic hypertrophy;
• DM;
• Parkinsonism
• Pregnancy.
• History of blood dyscrasias, myelosuppression, seizures; dementia; dyslipidaemia.
• Hypotension, bradyarrhythmia, hypoventilation; monitor BP carefully.