img

Olopatadine-an second-generation nonsedating antihistamine

Olopatadine hydrochloride is one of the second-generation nonsedating antihistamines that is used for treating allergic disorders such as urticaria, rhinitis More

Sharing is caring, show love and share the thread with your friends.

Description

Olopatadine hydrochloride is one of the second-generation nonsedating antihistamines that is used for treating allergic disorders such as urticaria, rhinitis

Generic Name

Olopatadine-an second-generation nonsedating antihistamine

Chemical names

Olopatadine; Patanol; Opatanol

Brand names

Alerchek, Arest, Dynolap, Neolap, O-Din, Ocupat, Olamyst, Olgeria, Olo, Oloblu, Olodin, Olopat, Opat, Pataday, Patanol, Winolap, Winolap Tab, X-Pat

IUPAC name

2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0³,?]pentadeca-1(15),3(8),4,6,11,13-hexaen-5-yl]acetic acid

Pharmacokinetics

Actions

Olopatadine is a selective histamine H1 antagonist that binds to the histamine H1 receptor. Olopatadine is devoid of effects on alpha-adrenergic, dopamine and muscarinic type 1 and 2 receptors. This block the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. 

Dosage/Dosage form

As 0.1% solution: 1 or 2 drops in the affected eye

Therapeutic uses

For the treatment of ocular itching associated with allergic conjunctivitis.

Adverse effects/Side effects

Asthenia; headache; cold syndrome; rhinitis; pharyngitis; sinusitis; ocular burning or stinging; dysgeusia; dry eye; foreign body sensation; hyperaemia; keratitis; lid oedema; ocular pruritus; blurred vision.

Interaction

Contraindications

Hypersensitivity

Storage

Store at 2-25°C.

Information

Molecular weight

337.4122

Molecular formula

C21H23NO3

CAS number

113806-05-6

Precautions

Remove contact lenses prior to admin. Reinsert soft contact lenses 10 min after admin. Pregnancy, lactation.