Orciprenaline (INN), also known as metaproterenol (USAN), is a bronchodilator used in the treatment of asthma. More
Orciprenaline (INN), also known as metaproterenol (USAN), is a bronchodilator used in the treatment of asthma.
Orciprenaline-also known as metaproterenol
Metaproterenol; Alupent; Metaprel; Metaproterenol sulfate
Alupent
5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol
It is a synthetic amine, structurally and pharmacologically similar to isoproterenol. Orciprenaline is used exclusively as a bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of ATP (adenosine triphosphate) to c-AMP (cyclic- 3',5'- adenosine monophosphate). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
20 mg 3-4 times a day as oral route, single dose as inhalation.
For the treatment of bronchospasm, chronic bronchitis, asthma, and emphysema.
Paradoxical bronchospasm, tachycardia, increased serum glucose, tremor, headache, increased potassium levels, palpitation, dizziness, insomnia, nausea, nervousness, vomiting, bad taste, heartburn, xerostomia, trembling, muscle cramps, weakness, coughing, pharyngitis, increased diaphoresis, hypertension, chest pain, angina, drowsiness, diarrhoea, taste change.
Contraindicated in patients with hypersensitivity, fast heart beat and abnormal heart rhythm.
Store at 15-25°C.
211.2576
C11H17NO3
586-06-1
CV disease, DM, glaucoma, hyperthyroidism, hypokalaemia, seizure disorders. Pregnancy and lactation.
