Orlistat- drug designed to treat obesity.

Orlistat is a medicine which can help you to lose weight if you are obese or overweight.

Orlistat- drug designed to treat obesity.

Orlistat; Tetrahydrolipstatin; Xenical; Alli

Cobese, Jm-Slim, Lipocut, Lipophage, O-Trim, Obelit, Obiless, Obitrol, Olisat, Orle, Orlean, Orlica, Orlife, Orlimac, Orlitroy, Reeshape, Troyslim, Vyfat, Zerofat

(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate

Orlistat is a reversible inhibitor of lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases. As undigested triglycerides are not absorbed, the resulting caloric deficit may have a positive effect on weight control.

120 mg tid with each main meal containing fat

Anti obesity drug.

Faecal urgency and incontinence, flatulence, fatty stools or discharge, increased defecation; headache, anxiety, fatigue, menstrual irregularities; abdominal pain/discomfort.

• May decrease absorption of oral fat-soluble vitamins, amiodarone, propafenone.
• May alter the effects of warfarin (monitor INR).
• May decrease plasma levels of ciclosporin.
• May elevate plasma levels of pravastatin.

Chronic malabsorption syndrome. Cholestasis. Lactation.

Store at 15-30°C (59-86°F).

Molecular weight

495.7348

Molecular formula

C29H53NO5

CAS number

96829-58-2

Precautions

• Distribute daily intake of fat over 3 main meals.
• Fat-soluble vitamins supplements may be required during long-term therapy.
• Discontinue use if 5% body wt loss is not achieved during the first 12 wk.
• History of hyperoxaluria or calcium oxalate nephrolithiasis.
• DM.
• Pregnancy.