Oxazepam- used for the treatment of anxiety and insomnia

Oxazepam is a short-to-intermediate-acting benzodiazepine. Oxazepam is used for the treatment of anxiety and insomnia

Oxazepam- used for the treatment of anxiety and insomnia

Tazepam; Adumbran; Serax; Droxacepam

Anxozap, Serepax

7-chloro-3-hydroxy-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Oral absorption, hepatic metabolism.

Oxazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation.

The recommended dose range is 10-30 mg in divided doses.

For the treatment of anxiety disorders and alcohol withdrawal.

Syncope (rare), oedema; drowsiness, ataxia, dizziness, vertigo, memory impairment, headache, paradoxical reactions (excitement, stimulation of effect), lethargy, amnesia, euphoria; rash; decreased libido, menstrual irregularities; incontinence; leukopenia, blood dyscrasias; jaundice; dysarthria, tremor, reflex slowing; blurred vision, diplopia; drug dependence.

• Reduced sedative effects with theophylline and other CNS stimulants. Increased incidence of headache with zidovudine. May reduce effects of levodopa.
• Additive CNS depression may occur with valerian, kava kava, St John's wort, gotu kola.
• Additive CNS depression with other CNS depressants and alcohol.

Pregnancy and lactation.

Store at 15-30°C

Molecular weight

286.713

Molecular formula

C15H11ClN2O2

CAS number

604-75-1

Precautions

• Cross-sensitivity with other benzodiazepines may occur.
• Hepatic and renal impairment.
• Respiratory disease.
• Debilitated patients, elderly, patients at risk of falls.
• Withdraw gradually.
• Porphyria; impaired gag reflex.
• History of drug abuse or acute alcoholism.
• May impair ability to drive or operate machinery.
• CV or cerebrovascular disease, intolerance to transient decreases in BP.
• Depression or if suicidal risk is present.