Oxcarbazepine-used to treat partial seizures in people with epilepsy.

Oxcarbazepine is an anticonvulsant drug primarily used in the treatment of epilepsy.

Oxcarbazepine-used to treat partial seizures in people with epilepsy.

Trileptal; Timox; Oxacarbazepine; Oxcarbamazepine

Alfox, Carbox, Mezalog, Oleptal OD, Oleptal-600, Oleptal-DT, Ox-Mazetol, Ox-Mezetol, Oxana, Oxana-SR, Oxcarb, Oxcazo, Oxep, Oxepin, Oxeptal, Oxetol, Oxetol-XR, Oxmazetol-SR, Oxpine, Oxrate, Oxzey, Seizurone OX, Selzic, Sel

9-oxo-2-azatricyclo[9.4.0.0³,?]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxamide

Oral absorption

Oxcarbazepine is structurally a derivative of carbamazepine, adding an extra oxygen atom to the benzylcarboxamide group. This difference helps to prevent the serious forms of anemia occasionally associated with carbamazepine and also reduce the impact on the liver of metabolizing the drug. Aside from this reduction in side effects, it is thought to have the same mechanism as carbamazepine - sodium channel inhibition - and is generally used to treat the same conditions.

600 mg/day in 2 divided doses initially, increase the dose gradually depends on response. 

Treatment of epilepsy, anxiety and mood disorders.

Stevens-Johnson syndrome, toxic epidermal necrolysis. Anaphylaxis and angioedema, somnolence, dizziness, headache, fatigue, ataxia, vertigo, amnesia, nervousness, abnormal thinking, insomnia, speech disorder, agitation, confusion; vomiting, nausea, abdominal pain, diarrhoea, dyspepsia, constipation, gastritis, weight gain; abnormal gait, tremor, weakness, back pain, abnormal coordination, dysmetria, sprains/strains, muscle weakness; diplopia, nystagmus, abnormal vision and accommodation; hypotension, leg oedema; rash, acne; hyponatraemia; rhinitis, chest infection, epistaxis, sinusitis.

• Reduced serum levels with carbamazepine, phenobarbitone, phenytoin, valproic acid. May reduce levels/effects of CYP3A4 substrates (e.g. benzodiazepines, calcium channel blockers, clarithromycin, ciclosporin, erythromycin, oestrogens, mirtazapine, nateglinide, nefazodone, nevirapine, protease inhibitors, tacrolimus, venlafaxine).
• Levels may be reduced with St John's wort. Evening primrose may reduce seizure threshold and reduce the effects of oxcarbazepine.
• May reduce efficacy of oral contraceptives.
• May increase levels of phenobarbitone, phenytoin.
• May reduce levels/effects of maraviroc. 

Hypersensitivity. Lactation

Store at 25°C (77°F).

Molecular weight

252.268

Molecular formula

C15H12N2O2

CAS number

28721-07-5

Precautions

• May impair ability to drive or operate machinery.
• Cross-sensitivity to carbamazepine may occur.
• Patients at risk of hyponatraemia.
• Do not discontinue abruptly. Renal and hepatic impairment.
• Pregnancy.