Oxiconazole-an antifungal medication

Oxiconazole is an antifungal medication typically administered in a cream or lotion to treat skin infections, such as athlete's foot, jock itch and ringworm.

Oxiconazole-an antifungal medication

Oxiconazol; Oxiconazolum; Oxyconazole

Zoderm, Zoderm-E

(Z)-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethylidene][(2,4-dichlorophenyl)methoxy]amine

This inhibits the ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Like other imidazole antifungals, Oxiconazole can increase membrane permeability to zinc, augmenting its cytotoxicity.

Topical-apply once/twice a day over the affected skin.

Used to treat vaginal candidiasis, Tinea cruris, Tinea corporis, Tinea pedis, Pityriasis versicolor.

Erythema, pruritus, rash, irritation, burning, folliculitis, stinging, nodules, papules, pain, maceration, fissuring, contact dermatitis, dyshidrotic eczema, tingling.

Hypersensitivity

Store at 15-30°C

Molecular weight

429.12

Molecular formula

C18H13Cl4N3O

CAS number

64211-45-6

Precautions

• Avoid contact with eyes.
• Pregnancy and lactation.
• Intravaginal preparation may damage latex contraceptives.
•  Cross-sensitisation with other imidazole derivatives may occur.
• Discontinue if irritation or sensitisation occurs.