Oxybutynin-an anticholinergic medication used to relieve urinary and bladder difficulties

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination

Oxybutynin-an anticholinergic medication used to relieve urinary and bladder difficulties

Oxybutynin; Ditropan; Oxytrol; Oxibutinina

Cystran, Ildamen, Nocturin, Oxyspas, Tropan

4-(diethylamino)but-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate

It is an anticholinergic, antispasmodic agent used for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Oxybutynin relaxes bladder smooth muscle. Oxybutynin exhibits only one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. Antimuscarinic activity resides predominantly in the R-isomer.

The recommended dose is 2.5 mg twice a day.

Anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination

Dry mouth, constipation, nausea, abdominal pain; blurred vision; headache, dizziness, drowsiness; dry skin, rash; photosensitivity, diarrhoea, insomnia, palpitation, weakness, dry eyes, confusion, hypertension, UTI, dyspepsia.

• Co-administration with other anticholinergic drugs may cause undesirable increased anticholinergic effects.
• Concentration may be increased by CYP3A4 inhibitirs (e.g. imidazole antifungals, macrolide antibiotics).
• Additive sedation with CNS depressants and alcohol. 

GI obstruction or atrophy, severe toxic megacolon, significant bladder outflow obstruction, glaucoma, urinary retention.

Store at 15-30°C 

Molecular weight

357.4864

Molecular formula

C22H31NO3

CAS number

5633-20-5

Precautions

• It should be used with caution in patients with hepatic or renal impairment, in the frail elderly, and in patients with myasthenia gravis.
• Elderly; hepatic or renal impairment; neuropathy; hyperthyroidism; prostatic hyperplasia; hiatus hernia; cardiac disease, reflux oesophagitis, ulcerative colitis, myasthenia gravis; pregnancy and lactation.
• Oxybutynin chloride may aggravate the symptoms of hyperthyroidism, coronary heart disease, congestive heart failure, cardiac arrhythmias, hiatal hernia, tachycardia, hypertension, myasthenia gravis, and prostatic hypertrophy.