Oxytetracycline-broad-spectrum tetracycline group of antibiotics

Oxytetracycline is an antibiotic.

Oxytetracycline-broad-spectrum tetracycline group of antibiotics

Terramycin; Oxytetracyclin; Oxitetraciclina; Adamycin

Foetocin, Genox, Labtocin, Oxter, Oxyteracin, Oxytetra, Oxytetracycline, Oxytetracycline INJ, Oxytetracycline OINT, Terramycin, Terramycin OINT, Terramycin-SF CAPS, Terramycin-SF CAPS, Terramycine-E OINT

(4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

NA

Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.

The recommended dose is 250-1.5g in divided doses.

Antibiotic

Anorexia, nausea, vomiting,diarrhoea, glossitis, dysphagia, photosensitivity, oesphageal irritation and ulceration, nephrotoxicity, enterocolitis, rash (rare), blood dyscrasias. Headache, visual disturbances; intracranial hypertension; bulging fontanelles (infants).

• Interferes with anticoagulant control.
• Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption.
• Absorption reduced by food, milk and milk products.
• Increased risk of ergotism with ergot alkaloids. May cause failure of oral contraception.
• Nephrotoxic effects exacerbated by methoxyflurane, diuretics, or other nephrotoxic drugs;
• Concurrent use may cause increased levels of lithium, digoxin, halofantrine and theophylline; decreased concentrations of atovaquone.
• Avoid concurrent use with potentially hepatotoxic drugs.
• Increased incidence of benign intracranial hypertension with retinoids.

• Hypersensitivity to tetracyclines, children <8 years, renal damage.
• Pregnancy, lactation.

Store it at room temperature and in air tight container.

Molecular weight

460.434

Molecular formula

C22H24N2O9

CAS number

79-57-2

Precautions

Myasthenia gravis; Elderly, hepatic or renal impairment; children <12 years, lupus erythematosus.