Phenoxybenzamine

Phenoxybenzamine

Dibenyline, Phenoxybenzamine, Dibenzyline, Dibenzyran, Dibenylin

Fenoben, fenoxene, fenoxene 50, Dibenzyline

Benzyl (2-chloroethyl)(1-phenoxypropan-2-yl)amine

Absorbed in the active form (20-30%) through oral administration.

Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phenoxybenzamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phenoxybenzamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.

Capsules, 10 mg, 50 mg

Antihypertensive Agent, Adrenergic alpha-Antagonists, Sympatholytics, Vasodilator Agents, pheochromocytoma.

Dizziness or fainting, postural hypotension, drowsiness, tachycardia, vomiting, fatigue, shock and lethargy.

• The risk or severity of adverse effects can be increased when Amiloride is combined with Phenoxybenzamine.
• Phenoxybenzamine may increase the hypotensive activities of Acebutolol, Alfuzosin, Acebutolol, and Aliskiren.
• The risk of adverse effects can be increased when Acetazolamide is combined with phaenoxybenzamine.

For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.

Protect from light and store in a dry place.

Molecular weight

185.22184

Molecular formula

C 18 H 22 ClNO

CAS number

59-96-1

Precautions

Phenoxybenzamine should not be given to patient with compensated congestive heart failure, & it should be used cautiously if there is cerebral or coronary arteriosclerosis or renal insufficiency.