Pilocarpine, pilocarpine nitrate

Pilocarpine, pilocarpine nitrate

(+)-Pilocarpine hydrochloride, Pilocarpal, Pilocar

Pilorin, pilomax, pilopress, pilomin, pilodrop, locarp

(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one

Metabolism: Inactivated at neuronal synapses and in plasma.

Excretion: urine

Pilocarpine is a cholinergic parasympathomimetic agent. It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors.

• Pilocarpine hydrochloride 5 and 7.5 mg oral tablets
• Eye drops 5 ml

Glaucoma

Lachrimation, blurred vision, vitreous haemorrhage, browache, pain and irritation

• Aminoglycosides, colistin, clindamycin, cyclopropane and halogenated inhalational anaesthetics, procainamide, quinine, β-blockers and lithium may reduce the efficacy of pilacarpine.
• Concomitant admin of 2 miotics may increase risk of toxic reactions.
• Concurrent use with β-blockers may lead to bradycardia.

Lactation, Angle-closure glaucoma, anterior uveitis, acute iritis, hypersensitivity, Pregnancy.

• Oral: Store at 2-27°C.
• Ophthalmic: Store <8°C. Do not freeze. 

Molecular weight

244.719 g/mol

Molecular formula

C11H16N2O2

CAS number

92-13-7

Precautions

Prolonged use may lead to lens opacities. Patients with renal impairment, cognitive or psychiatric disorders, biliary tract disorders.