Propranolol

Propranolol

Propanolol, Dociton, Beta-Propranolol, Avlocardyl, Euprovasin

Hemangeol, Inderal, Inderal XL, Inderal LA, Innopran XL

1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol

• Absorption: GI tract
• Distribution: Crosses the blood-brain barrier and placenta, enters breast milk. Protein-binding: 90%.
• Metabolism: Hepatic
• Excretion: Urine

Propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta (1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.

• Hemangeol solution-4.28 mg/mL orally
• Inderal 20 Tab 20mg

Used as diuretic, anti hypertensive agent, vasodilator, ganglionic blocker, anti arrhythmia, anti angina agent.

Nausea, vomiting, diarrhea, constipation, stomach discomfort, fatigue, nonthrombocytopenic purpura, hallucination.

• Increased serum levels of thioridazine when used with propranolol.

• Decreased effect with aluminum and calcium salts, NSAIDs, ampicillin, rifampicin.
• Concurrent use with chlorpromazine results in raised blood levels of both drugs and additive hypotensive effect. 

Sinus bradycardia, pregnancy, cardiogenic shock, lactation, pulmonary oedema, severe hyperactive airway disease

Store at 20-25°C

Molecular weight

259.349 g/mol

Molecular formula

C16H21NO2

CAS number

525-66-6

Precautions

Propranolol should be used with caution in patients with impaired hepatic or renal function.