Rabeprazole

It is a proton pump inhibitor that suppresses gastric acid production in the stomach.

Rabeprazole

Rabeprazole; Aciphex; Habeprazole; Pariets

Abepra-DSR, Abex, Abex-D, Abex-DSR, Above-5, Above-5-D, Abra, Abra-D, Acera, Acera-D, Acidom, Acirab, Acirab-D, Acirab-DSR, Acistal, Acistal-D, Adec, Adec-R, Affirab, Affirab-D, Albera, Algibra, Algibra-D, Altirab, Altirab-D, Altirab-DSR, Altrab, Altrab-D, Altrab-DSR, Anarub-DSR, Anslag, Anslag-D, Antuc, Antuc-DSR, Aptase-DSR, Aribzol, Aribzol-D, Arpiz-DSR, Arpiz-Fast, Arzola, Arzola DSR, Asalt, Asalt-D, Asirab, Asirab-D, Asterab-DSR, Aurizol-R, B-Joy, B-Joy Plus, Be

2-{[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methanesulfinyl}-1H-1,3-benzodiazole

• Bioavailability 54%
• Protein binding 97%
• Extensively metabolized by liver

Rabeprazole prevents the production of acid in the stomach. This decreases the symptoms and prevents injury to the stomach or esophagus in patients with GERD (gastroesophageal reflux disease) or ulcers. Rabeprazole is also useful for Zollinger-Ellison syndrome. Rabeprazole may also be used with antibiotics to get rid of bacteria that are associated with some ulcers. By inhibition of the ATPase, H⁺ and K⁺ which is found at the secretory surface of parietal cells, rabeprazole suppress the gastric acid secretion.

• PO- Gastro-oesophageal reflux disease; erosive oesophagitis: 20 mg once daily in the morning for 4-8 weeks. Maintenance: 10-20 mg once daily. 
• 10 mg once daily for 4 wk, upon symptom resolution, may continue with 10 mg once daily when needed for non-erosive oesophagitis.
• Healing of Duodenal Ulcers: 20 mg/day after the morning meal for 4 weeks; additional therapy may be required for some patients.
• Zollinger-Ellison: 60 mg once daily. Adjust according to patient’s needs.

For the treatment of

• Peptic ulcer disease
•  Acid-reflux disorders (GERD),
• H. pylori eradication
•  And prevention of gastroinetestinal bleeds with NSAID use.

Headache, diarrhoea, rash, infection and flu-like syndrome. Dizziness, fatigue, constipation, nausea and vomiting.

• May reduce absorption of ketoconazole and itraconazole. May prolong the elimination of diazepam, phenytoin and warfarin.
• Delayed absorption with high-fat meals.

Hypersensitivity

Store at 15-30°C

Molecular weight

359.443

Molecular formula

C18H21N3O3S

CAS number

117976-89-3

Precautions

Severe hepatic impairment, gastric malignancy. May increase the risk of GI infections due to acid suppressive effects. Pregnancy.