Ramipril

It is an angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure (hypertension) and congestive heart failure. By inhibiting an enzyme, ACE inhibitors relax the muscles around small arteries (arterioles).

Ramipril

Ramipril; 87333-19-5; Tritace; Altace; Carasel

Acepril, Acepril Tab, Acepril-A, Alvace, Amlokos-R, Atamra-CV, Cardace, Cardace-AM, Cardiopril, Conram, Cordimil, Corpril, Corpril-AM, Cupril, Dexace, Ecator, Emipril, Etoril, Gopril, Hecril, Hopace, Hopace-AM, Hopecard, Hopecard 2.5-AM, Hoperam, Kapril, Lifepril, Macpril, Macpril H, Megapril, Metoz-R, Mypril, Mypril-AM, Odipril, Olmy-R, Orvoram, Pepnipril-H, Preface, Prilace, Prilcard, R-Cord, R-Pril, R. Pril, Race, Ramace, Ramace Tab, Ramcor, Ramey, Ramic, Ramic-Forte

(2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid

NA

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• Hypertension- Initial: 1.25 mg at bedtime. Maintenance: 2.5-5 mg/day as a single dose, up to 10 mg/day if needed. 
• Heart failure- Initial: 1.25 mg once daily. Max: 10 mg/day. 
• Myocardial infarction (Heart Attack) - Start 3-10 days after infarction. Initial: 2.5 mg twice daily after 2 days, then 5 mg twice daily. Maintenance: 2.5-5 mg twice daily.

For the management of mild to severe hypertension. May be used to reduce cardiovascular mortality following myocardial infarction in hemodynamically stable individuals who develop clinical signs of congestive heart failure within a few days following myocardial infarction.

Angioneurotic oedema of face, vomiting, diarrhoea, fatigue, dizziness, headache, abdominal pain, and cough. Rarely symptomatic hypotension. Nausea, glottis and larynx, lips, tongue, syncope, renal impairment, hypersensitivity reactions.

• NSAIDs may increase risk of deterioration of renal function.
• Concomitant admin of diuretics may lead to serious hypotension.
• May increase serum lithium concentration.

• Hypersensitivity, bilateral renal artery stenosis, or a single kidney with unilateral renal artery stenosis.
• Aortic stenosis or outflow tract obstruction.
• Pregnancy and lactation.

Store it in an airtight container

Molecular weight

416.5106

Molecular formula

C23H32N2O5

CAS number

87333-19-5

Precautions

• Renal impairment, hypovolaemia, hyperkalaemia, valvular stenosis; before, during or immediately after anaesthesia.
• Severe resistant hypertension, elderly, peripheral vascular disease or generalised atherosclerosis.
• Regular monitoring of WBC in patients with vascular collagen disorders is recommended.
• Monitor renal function before and during treatment.
• Use with caution in patients with history of hereditary angioedema or idiopathic.