Ranolazine

Ranolazine is an antianginal medication.

Ranolazine

Ranexa; N-(2,6-dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide; CVT-303

Caroza, Rancad, Ranolaz, Ranolaz-OD, Ranozex, Ranx, Razine, Revulant, Rolazin

N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide

Hepatic metabolism.

Ranolazine has antianginal and anti-ischemic effects that do not depend upon reductions in heart rate or blood pressure.

Initial dose of 500 mg twice daily. The dosage can be increased to 1000 mg twice daily, if needed.

For the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates.

Dizziness, nausea, weakness, constipation and headache. Abdominal pain, dry mouth and vomiting. 

• Ranolazine may interact with dexamethasone, arsenic trioxide, digoxin, fluconazole, tamsulosin, chloroquine, lovastatin, fluoroquinolones, statins, methadone, tolterodine, anti-depressant drugs, anti-ADHD drugs, anti-fungal drugs, anti-cancer drugs, anti-tussives, anti-emetics, amiodarone, zolmitriptan, beta-blockers, chlorpromazine, haloperidol, phenergan, pimozide, cyclosporine, sumatriptan, codeine, morphine and tramadol.
• Avoid consuming grapefruit, wine or grapefruit juice while taking Ranolazine. It may cause serious drug reactions.

Contraindicated in patients who are taking certain azole antifungals, liver impairment and hypersensitivity.

Store at 20-25°C.

Molecular weight

427.5365

Molecular formula

C24H33N3O4

CAS number

95635-55-5

Precautions

• Ranolazine may impair thinking and alertness.
• Do not drive vehicles or operate heavy machineries while taking Ranolazine.
• The drug is contraindicated in patients with QT prolongation.