Rifampicin or rifampin

Rifampicin, also known as rifampin, is an antibiotic used to treat several types of bacterial infections, including tuberculosis, leprosy, and Legionnaire's disease.

Rifampicin or rifampin

Rifampicin; Rifadin; Rifampin; Rimactane; Rifampicinum; Rifaldazine

Coxid-450, Coxkit- 3, Eufacin, Famcin, Kemorifa, Ls-Rif, Macox, Monocin, Montomycin, R-Cin, Rifacept, Rifacilin, Rifampila, Rifamycin, Rifaplus CAPS, Rimactane, Rimpacin, Rimpin, Ripharmed, Scc-2, Taurif, Ter-4, Ticin, Zucox

(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(1E)-[(4-methylpiperazin-1-yl)imino]methyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1?,?.0?,²?]

89% protein binding.

This is acted via the inhibition of DNA-dependent RNA polymerase, and then leads to the suppression of RNA synthesis and cell death.

The recommended dosage is 10 mg/kg/day or 2-3 times/week. Max: 600 mg/day per oral.

For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.

Thrombophloebitis; fatalities in those with liver disorders, influenza- like symptoms, skin reactions, eosinophilia, transient leucopenia, thrombocytopenia, purpura, abnormalities of liver function, shock, drowsiness, headache, ataxia, visual disturbances, menstural irregularities. Reddish coloured urine & tears. Hepatitis or shock like syndrome with hepatic involvement.

• Increased metabolism of chloramphenicol, losartan & its active metabolite, clofibrate, dapsone, digoxin, hexobarbitone, ketaconazole & quindine.
• Increased metabolism of diazepam & nitrazepam.
• Rifsmpicin used with anticholingergics, opioids, antacids & ketaconazole the absorption rate may be decrease.
• Serum levels of bunazosin, aprepitant, bisoprolol, atovaquone, metoprolol, carvedilol, proanolol, buspirone, diltiazem, nifedipine & verapamil may be reduced.
• Increased risk of translant rejection when used with ciclosporin, Deceases effects of tolbutamide, clofibrate, coumarin anticoagulates, diazepam & oral contraceptives.

Hypersensitivity, jaundice, severe hepatic disease. IM/SC admin. Porphyria. Not to be used for treatment of meningcoccal disease.

Store it at room temperature.

Molecular weight

822.9402

Molecular formula

C43H58N4O12

CAS number

13292-46-1

Precautions

• Impaired hepatic or renal function.
• Elderly, malnourished or very young patients.
• Alcoholic patients.
• Monitor blood counts & liver function regularly.
• Body fluids may colour red.
• Discontinue use if thrombocytopenia or use if thrombocytopenia or purpura occurs.
• Pregnancy & lactation.
• Care should be taken during IV admin to prevent extravasation.