Rifaximin

Rifaximin, sold under the trade name Xifaxan among others, is an antibiotic used to treat traveler's diarrhea, irritable bowel syndrome, and hepatic encephalopathy.

Rifaximin

Rifaximin; Rifaxidin; 80621-81-4; Rifacol; Xifaxan

Rcifax, Refatime, Rfx, Rifagut, Rixmin, Sibofix, Torfix

(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.1?,?.0?,³?.0²?,³?.0²?,³²]heptatriaconta-1,3,5(35),9

Low absorption

Rifaximin is a structural analog of rifampin and a non-systemic, gastrointestinal site-specific antibiotic. This non-systemic property of the drug is due to the addition of a pyridoimidazole ring, which renders it non-absorbable. 

• It is administered orally in a dose of 600 mg in 3 divided doses for a 3-day course for traveller’s diarrhoea. 

• It is administered as 1100 mg/day in 2 divided doses for Hepatic Encephalopathy.

• Hepatic Encephalopathy
• prescribed for the treatment of traveller’s diarrhoea due to Escherichia coli infections

Chest pain, uneasiness, weakness, and hot flashes. Constipation, abdominal distension, vomiting, dry throat, diarrhea, fecal abnormality, hernia, gingival disorder, dry lips, stomach discomfort, dysentery, blood in stool, loss of appetite, loss of taste. 

• When it is combined with 2-mercaptobenzothiazole, Alectinib the serum concentration of Rifaximin can be increased.
• when combined with Rifaximin, the serum concentration of Acebutolol can be decreased
• The risk or severity of hypotension can be increased when Rifaximin is combined with Agmatine.

Contraindicated in patients with severe hepatic diseases, watery or bloody diarrhoea, diarrhoea with underlying pyrexia.

Store at 20-25°C.                       

Molecular weight

785.8785

Molecular formula

C43H51N3O11

CAS number

80621-81-4

Precautions

• It may cause dizziness, do not drive a car or operate machinery while taking this medication.