Risperidone

Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication. It is mainly used to treat schizophrenia, bipolar disorder, and irritability in people with autism.

Risperidone

Risperidone; Risperidal; Risperdal; Risperdal Consta

Cinris, Cinris Forte, Don Forte, Don Plus, Don-LS, Eritric, Etores-TR, Genrest, Genrest Plus, Genrest-LS, Krisp, Krisp-T, Peridon, Psydon, Psydyl, R-Don, R-Don Forte, R-Don Plus, R-Don T, Regrace, Regrace Forte, Regrace Plus, Resistar Forte, Resistar Plus, Respidon, Ridon, Riscalm, Riscalm Forte, Riscalm-LS, Riscalm-Plus, Rischro, Risclam, Riscon, Riscon Forte, Riscon Plus, Riscon-LS, Risdil Plus, Risdone, Risdone Plus, Riset, Riset Forte, Riset Plus, Risfine, Risfine-T, Risipe, Risnia, Risnia Forte, Risnia Plus, Risolla, Risperdal

3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one

Well absorbed orally.

Risperidone decreases the serotonergic and dopaminergic pathway activity in the brain, therefore decreasing symptoms of schizophrenia and mood disorders.

The recommended initial dose is 2 mg/day by orally, increase from day 2 if necessary to a maximum of 16 mg/day.

It is widely used in the treatment of schizophrenia and mood disorders, including bipolar disorder and depression with pyschosis.

Agitation, anxiety, dizziness, headache, somnolence; orthostatic hypotension; constipation, dyspepsia, nausea, vomiting, abdominal pain, blurred vision, erectile dysfunction, priapism, rhinitis, rash and allergy, galactorrhoea, gynaecomastia, menstrual disorders, extrapyramidal symptoms (rarely). Weight gain, oedema, tardive dyskinesia.

• May antagonise the effects of levodopa and dopamine agonists.
• May increase serum levels of clozapine when used together.
•  Concurrent use with carbamazepine may increase serum levels.
• Risperidone may enhance the hypotensive effect of certain antihypertensives.
•  Increased risk of neuroleptic malignant syndrome when used with indinavir and ritonavir.

Hypersensitivity.

Store at 15-25°C

Molecular weight

410.4845

Molecular formula

C23H27FN4O2

CAS number

106266-06-2

Precautions

• Parkinsonism; elderly, discontinue use if signs and symptoms of tardive dyskinesia occur; epilepsy; renal and hepatic impairment, pregnancy.
• May cause drowsiness and orthostatic hypotension. Gradual withdrawal is recommended.
•  Monitor blood glucose in diabetics and patients at risk of developing diabetes.