Ritonavir

Ritonavir, sold under the trade name Norvir, is an antiretroviral medication used along with other medications to treat HIV/AIDS.

Ritonavir

Ritonavir; Norvir; ABT-538; A-84538

Empetus, Ritomax, Ritovir, Synthivan

1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate

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PO- HIV infection: The recommended dose is 600mg, two times per day.

Indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.

Syncope, orthostatic hypotension; dry mouth, mouth ulcers, throat irritation, cough; dyspepsia, nausea, vomiting, diarrhoea, taste disturbance, seizures, anxiety, sweating, fever, asthenia, fatigue, headache, dizziness, paraesthesia, myalgia, skin rashes, pruritus, renal insufficiency, anaemia, raised WBC, raised prothrombin time, lipodystrophy, pancreatitis, electrolyte imbalance.

• Avoid concurrent admin of oral solution (contains alcohol) with disulfiram or metronidazole.
• Increased risk of myopathy when used with simvastatin or lovastatin.
• Concurrent use with alfuzosin may lead to serious hypotension.
• When used with quinidine, amiodarone, propafenone, cisapride, pimozide and flecainide increases the risk of cardiac arrhythmias.
•  Risk of acute ergot toxicity when used with ergot derivatives.
• Co-admin with St. John's wort may lead to a substantial decrease in the plasma levels of ritonavir.
•  Increased risk of serious adverse reactions when used with midazolam or triazolam.

Hypersensitivity; lactation; severe hepatic impairment

Store it in refrigerator, do not freeze it.

Molecular weight

720.944

Molecular formula

C37H48N6O5S2

CAS number

155213-67-5

Precautions

• Monitor lipid, glucose, uric acid and blood counts.
• Pregnancy; DM; child; hepatic impairment; pancreatitis, haemophilia;
• Ensure adequate hydration to reduce risk of nephrolithiasis.
• Discontinue treatment if patient develops haemolytic anaemia.