Rosuvastatin

Rosuvastatin (INN), marketed under the tradename Crestor, is a member of the drug class of statins, used in combination with exercise, diet, and weight-loss to treat high cholesterol and related conditions, and to prevent cardiovascular disease.

Rosuvastatin

Crestor; Rosuvastatin; Rosuvastatin calcium; Creston (TN)

Akroz, Arvast, Arvast-F, Bestor, Bestor-FN, Crestor, Crevast, Fenovas, Fortius, Fortius-20, Herocin, Jprest, Ldnil, Lipirose-F, Multistat, Novastat, Novostat, R2, R2-F, Razel, Razel-EZ, Razel-F, Razel-FX, Rolistat, Rolistat-F, Rosact, Rosat, Roseday, Roseday-F, Rosevast, Rosidoc, Rosmi, Rosofibric, Rosta, Rostar, Rostar-F, Rosulex, Rosuline, Rosulip, Rosulip-F, Rosumac, Rosumac-F, Rosutec, Rosuvakare, Rosuvas, Rosuvas-EZ, Rosuvas-F, Rosuvastat, Rosyn, Rosytab

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid

NA

It belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

The recommended dose is 5 to10 mg/day may increase slowly to 20 mg/day if needed. Max: 40 mg/day.

Used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. 

Headache, dizziness, constipation, nausea, vomiting, abdominal pain, myalgia, chest pain, peripheral oedema, depression, insomnia, rash, paraesthesia, proteinuria and asthenia.

• Risk of myopathy increased when used with gemfibrozil.
• By fluconazole, serum levels may be increased.
• May increase serum levels of warfarin and oral contraceptives.
• With ciclosporin increased risk of renal failure and serious myopathy.
•  Concurrent admin with aluminium/magnesium hydroxide may lead to decreased bioavailability of rosuvastatin.

Pregnancy, lactation. Unexplained persistent elevations of serum transaminases; severe renal impairment, active liver disease, hypersensitivity.

Store at 20-25°C

Molecular weight

481.538

Molecular formula

C22H28FN3O6S

CAS number

287714-41-4

Precautions

• Not to be used in patient with major surgery, sepsis, hypotension, trauma, severe metabolic, endocrine and electrolyte disorders or uncontrolled seizures.
• History of liver disease and alcoholism.
• If there is marked or persistent increase in serum aminotransferase concentrations, significant increases in creatinine phosphokinase or evidence of myopathy discontinue treatment.