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Roxithromycin

Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. More

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Description

Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections.

Generic Name

Roxithromycin

Chemical names

Roxithromycin; Roxithromycine; Roxithromycinum; Roxitromicina; Rulide

Brand names

Actirox, Ambroxit, Amrox, Arbid, Arbid-A, Artirox, Artirox-SP, Atrox, Aurox 150, Aurox 50Mg, Aurox-Kid, Avirox, Avirox Forte, Avirox- ST, Avirox-AM, BD- Rox, Bio-Throx, Biorox, C-Rox, Canrox, Canrox-A, Curox, Cyrox, Derox, E-Rox, Emrox, Emrox-DT, Entrox, Flanzen-RX, Geerox, Goodrox, Hirox, Hycin, Inrox, Kevrox, Kevrox-S, Kevrox-SA, Leolide, Luprex, Maclong Macrox-150, Med-Rox, Medirox, Medirox-A, Mgrox, Myrox, N-Rox, Nuroxy, Odirox, Odirox Kid

IUPAC name

(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl

Pharmacokinetics

NA

Actions

NA

Dosage/Dosage form

The recommended dose is 150 mg twice daily or 300 mg once daily for 5-10 days per oral.

Therapeutic uses

Prescribed for the treatment of urinary infections, respiratory tract, and soft tissue infections.

Adverse effects/Side effects

Nausea, vomiting, abdominal pain, diarrhoea, weakness, malaise, anorexia, constipation, dyspepsia, flatulence; hepatitis; rashes, headache, dizziness, weakness, changes in blood counts; increased liver enzyme values; eosinophilia; rarely, acute pancreatitis.

 

Interaction

 May raise serum levels of ciclosporin and digoxin. Increased risk of rhabdomyolysis when used with simvastatin.

Contraindications

Hypersensitivity. Porphyria

Storage

Store it at room temperature.

Information

Molecular weight

837.0465

Molecular formula

C41H76N2O15

CAS number

80214-83-1

Precautions

Hepatic impairment. Monitor liver function. Prolonged treatment increases risk of hepatotoxicity. History of arrhythmias.